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hepatitisviruses肝炎病毒-資料下載頁

2025-07-15 22:52本頁面
  

【正文】 detect HCV RNA Treatment防治原則 ? No vaccine尚無可用疫苗 ? Rebinant IFNαalone or with ribavirin 病毒唑 hepatitis D virus, HDV 丁型肝炎病毒 ? a defective virus that acquires an HBsAg coat for transmissionHDV是缺陷病毒,需以 HBsAg構成其衣殼來傳播 ? circular, singlestranded RNA molecules and an internal core δ antigen (HDAg) 單負鏈環(huán)狀 RNA和 δ 抗原( HDAg) Pathogenesis ? spread by the same routes as HBV: blood, semen, and vaginal secretions 傳播途徑與 HBV相同:血液,精液,陰道分泌物 ? increases the severity of HBV infections: Fulminant hepatitis 加重 HBV感染:爆發(fā)性肝炎 – Coinfection聯(lián)合感染 – Superinfection重迭感染 Laboratory diagnosis ? detecting the delta antigen , RNA or antibodies病原學檢查為 HDAg、 抗 HDV及 HDVRNA ? AntiHDV IgM ? Persistant AntiHDV IgG chronic infection Treatment and prevention ? no known specific treatment ? prevention of infection with HBV prevents HDV infection. hepatitis E virus, HEV 戊型肝炎病毒 ? spherical, nonenveloped, and 2734 nm 球形,無包膜, ? a positivesense, singlestrand RNA genome 單正鏈 RNA ? spread by the fecaloral route為糞-口途徑傳播 ? symptoms and course of HEV disease are similar to those of HAV disease 癥狀病程類似 HAV ? Acute hepatitis , mortality rate : 1% to 2% ? especially serious in pregnant women (mortality rate of approximately 20%)孕婦感染嚴重 ,病死率高達 20% Diagnosis 微生物學檢查 ? HEV: EM or IEM電鏡或免疫電鏡 ? AntiHEV IgM ? HEV RNA 五種肝炎病毒比較 HAV HBV HCV HDV HEV 病毒結構 +ssRNA dsDNA +ssRNA ssRNA +ssRNA 傳播途徑 糞 口 血液、性、垂直傳播 糞 口 病情 輕 偶爾嚴重 亞臨床 ,慢性多見 需 HBV協(xié)助 孕婦重 慢性及攜帶者 無 有 無 實驗室檢查 抗 HAV IgM HBsAgAb HBcAb HBeAgAb 抗 HCV HCVRNA 抗 HDV IgM 抗 HEV IgM 預防 疫苗 疫苗 無 同 HBV 預防為主
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