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000。 53(56): 26671.21 Bettany JT, Peet NM, Wolowacz RG et al. Tetracyclines induce apoptosis in osteoclasts. Bone. 2000。 27(1): 7580. 22 Lopatkin NA, Kamalov AA, Kudriavtsev IV. Fluorescent diagnostics of urinary bladder cancer. Urolog IIa. 2000。 (4): 36.23 Spahn JD, Fost DA, Covar R et al. Clarithromycin potentiates glucocorticoid responsiveness in patients with asthma: Results of a pilot study. Ann Allergy Asthma Immunol 2001。 87(6):501524 Frazee LA, Mauro LS. Erythromycin in the Treatment of Diabetic Gastroparesis. Am J Ther. 1994。 1(4): 287295. 25 Yeo AE, Rieckmann KH, Christopherson RI. Indirect inhibition by antibiotics of nucleotide and deoxynucleotide biosynthesis in Plasmodium falciparum. Southeast Asian J Trop Med Public Health. 1998。 29(1): 246. The nonantibacterials effects of antibacterials SONG Hui, SHENG Xiaogang1, QIAN Yuanshu. ( Deptment of pharmacology of Shantou University Medical College, Shantou 515031)ABSTRACT The effects of antibacterials are mainly focus on inhibiting the proliferation of the bacteriums or killing them directly in various ways. Consequently, antibacterials were mainly used in the therapy of infectious diseases. However, besides the effect of antibacterials, some antibacterials have other effects as well, such as the effects of antitumor, immunomodulation and antivirus etc. So it is very important to understand the effects and their mechanisms of antibacterials roundly so as to apply them more rationally. KEY WORDS antibacterials/antibiotics。 nonantibacterial effect。 immunomodulation。 ttumor。 virus 1 Guang Dong Cardiologic Diseases Research Institute, Guangzhou 5101002002 0116收稿,2002 0424修回1 廣東省心血管病研究所,廣州 510100作者簡(jiǎn)介:宋 卉,女,講師,藥理學(xué)博士生,研究方向:抗菌藥物。 E mail:sophie1011@ Tel: 07548900432 錢元恕,男,教授,博士生導(dǎo)師,研究方向:抗菌藥物。E mail:qys49@ Tel: 07548900432(O)/8529785(H)11 / 11