細(xì)胞凋亡華子春ppt課件-資料下載頁(yè)
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【正文】 nformational changes Apoptosis Is Activated by Binding to Adaptor Proteins to Form Aggregates F a sT N F R ID R 3D R 4 / D R 5 /T R A I L RD e a t h d o m a i nD R 6F a s F a s L F A D D C a s p a s e 8 A P O P T O S I S Activation of Apoptosis from Outside the Cell Death receptors ? Killer lymphocytes produce Fas ligand to bind to Fas protein (death receptor) on target cells ? Adaptor proteins aggregate caspase 8, which crossactivate Some damaged cells produce both Fas ligand and Fas protein for selfdestruction Extrinsic pathway APOPTOSIS: control Intrinsic pathway (damage): Mitochondria Cytochrome c release Procaspase 9 cleavage Proexecution caspase (3) cleavage Caspase (3) cleavage of cellular proteins, nuclease activation, etc. Death BAX BAK BOK BCLXs BAD BID B IK BIM NIP3 BNIP3 BCL2 BCLXL BCLW MCL1 BFL1 DIVA NR13 Several viral proteins Activation of Apoptosis from Inside the Cell Intrinsic pathway When cells are damaged: ? Mitochondria release cytochrome c ? In cytosol, cytochrome c binds to Apaf1 (adaptor protein) ? Apaf1 aggregates of procaspase 9 ? p53 activates transcription of Bcl2 family Bcl2 Family Proteins and IAP proteins Regulates Apoptosis Members of the Bcl2 family have different roles: ? Bcl2, BclX, etc: Inhibit apoptosis by blocking cytochrome c release ? Bad: Promotes apoptosis by binding to and inactivating Bcl2, BclX, etc, ? Bax, Bak, etc: Stimulate the release of cytochrome c The IAP (inhibitor of apoptosis) family inhibit apoptosis: ? Bind to procaspases to prevent their activations ? Bind to caspases to prevent their activity Mitochrondria release cytochrome c AND inhibitors of IAP to fully start the apoptosis Cell proliferation 謝 謝 ！ Thanks for your kind attention
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