干細(xì)胞與中樞神經(jīng)系統(tǒng)發(fā)育-資料下載頁
2025-01-18 11:47本頁面
【正文】 s (forebrain) subventricular zone (next to the ependymal zone), hippocampus spinal cord Cerebra cortex. cerebellum 成人骨髓間充質(zhì)干細(xì)胞 Mesenchymal stem cells of the bone marrow（ MSCs） ? 分化為骨、軟骨、結(jié)締組織、脂肪、神經(jīng)組織，等 ? PDGF, EGF, bFGF, IGF1促增殖 ? Markers: ? 細(xì)胞因子受體： interleukin1, 3, 4, 6, and 7 receptors。 ? 細(xì)胞外基質(zhì)受體： ICAM1 and 2, VCAM1,ALCAM, Endoglin, 透明質(zhì)酸受體，整合素 alpha1, 2, 3， A， V integrins； beta1, 2, 3 and 4 integrins. ? 生長因子受體： BFGFR, PDGFR ? 其他受體： Thy1, INFγR, TGFβR， TNFR 神經(jīng)元局限性前體細(xì)胞 神經(jīng)元局限性前體細(xì)胞 Nestin+/ MAP2+/ PASNCAM+???/ 腦區(qū)特異性標(biāo)志 分裂期后的神經(jīng)元 形態(tài)學(xué)，電生理活性，神經(jīng)遞質(zhì)合成，神經(jīng)遞質(zhì)反應(yīng) 分化 去分化 神經(jīng)元局限性前體細(xì)胞 神經(jīng)元局限性前體細(xì)胞 Nestin+/ MAP2+/ PASNCAM+/ 腦區(qū)特異性標(biāo)志 分裂期后的神經(jīng)元 形態(tài)學(xué)，電生理活性，神經(jīng)遞質(zhì)合成，神經(jīng)遞質(zhì)反應(yīng) 分化 去分化 神經(jīng)元局限性前體細(xì)胞 神經(jīng)元局限性前體細(xì)胞 Nestin+/ MAP2+/ PASNCAM+???/ 腦區(qū)特異性標(biāo)志 分裂期后的神經(jīng)元 形態(tài)學(xué)，電生理活性，神經(jīng)遞質(zhì)合成，神經(jīng)遞質(zhì)反應(yīng) 分化 去分化 膠質(zhì)局限性前體細(xì)胞 多能干細(xì)胞 膠質(zhì)局限性前體細(xì)胞 A2B5+, nestin+,PLPDM20+, +, PDGFRa O2A前體細(xì)胞 A2B5+, nestin+, PDGFRa+, GD3+ 星型膠質(zhì)前體細(xì)胞 A2B5+, nestin+, vimentin+ 少突膠質(zhì)細(xì)胞 O4+, O1+, PLP+ II型型型膠質(zhì)細(xì)胞 A2B5+, nestin+, GFAP+ 型型膠質(zhì)細(xì)胞 Ran2+, GFAP,FGFR3+ Figure 4: (A) Transplanted adult neural stem cells differentiate into neurons in the adult hippocampal dentate gyrus. Neuronal markers NeuN (red), Tuj1 (blue). BrdU in green. (B) The same population fails to differentiate into neurons after transplantation into the adult substantia nigra, demonstrating that environmental signals regulate the neuronal differentiation of adult neural stem cells. Tyrosinehydroxylase in blue, glial marker NG2 in red, BrdU in green. Journal of Neuroscience, 2022. 神經(jīng)干細(xì)胞在轉(zhuǎn)基因和腦組織修復(fù)中應(yīng)用的研究進(jìn)展 ? 建立永生化神經(jīng)先祖細(xì)胞系 使神經(jīng)元干細(xì)胞的方法 永生化細(xì)胞系作為腦內(nèi)植入和基因轉(zhuǎn)移 ? 永生化細(xì)胞系移植與基因治療 用作神經(jīng)營養(yǎng)因子轉(zhuǎn)基因載體 用作遞質(zhì)合成酶轉(zhuǎn)基因載體 用作代謝酶轉(zhuǎn)基因載體
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