anticonvulsanttherapy-bcepilepsysociety：抗驚厥療法-公元前癲癇協(xié)會(huì)-資料下載頁
2025-01-12 06:44本頁面
【正文】 ? Suicidal behavior Rufinamide (BanzelR) ? Advantages ? Effective in LennoxGastaut Syndrome ? Well tolerated ? Disadvantages ? Drowsiness ? Headache ? Unsteadiness ? Loss of appetite ? Rare ? Heart arrhythmia ? Rash ? Suicidal behavior Ezogabine (PotigaR) ? Advantages ? Effective for focal seizures ? Well tolerated ? Disadvantages ? Three times daily dosing ? Drowsiness ? Dizziness ? Urinary Retention ? Rare ? Bluish Pigmentation ? Skin ? Sclera ? Retina Drug Interactions Why do drug interactions occur? ? Increase breakdown of other drugs ? Decrease breakdown of other drugs Drug Interactions: Birth Control Pill ? Reduce Effectiveness ? Carbamazepine ? Oxcarbazepine ? Phenobarbital ? Phenytoin ? Topiramate ? Lamotrigine ? No Effect ? Clobazam ? Clonazepam ? Ethosuximide ? Gabapentin ? Levetiracetam ? Valproic Acid Stopping AED Therapy ? Need to continue AED therapy should be reevaluated after 2 years seizures free. ? Factors favoring low risk recurrence ? Minimum 2 years seizure free ? Normal EEG ? Normal Neurological Examination ? Ease of controlling seizures ? Slow withdrawal of medications: ? over 23 months Anticonvulsant Medication and Pregnancy Anticonvulsants and Pregnancy ? 90% of women with epilepsy will have a healthy baby ? Slightly higher risk for congenital malformations ?General population: 23% ?Untreated epilepsy: 25% ?All anticonvulsant drugs: 47% Anticonvulsants and Pregnancy ? Planned Pregnancy ? Talk to doctor ? Ideally one drug at lowest possible dose ? Monotherapy: % vs polytherapy 7% ? Folic Acid ? ? Higher dose (45mg/day): women with epilepsy of child baring age Conclusion ? Epilepsy is mon ? We treat seizures to prevent injury and maintain active lifestyle ? We select anticonvulsant medications ?Seizure types, drug profile, individual factors ? Adverse Effects ? Drug Interactions ? Anticonvulsants and Pregnancy
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