anticonvulsanttherapy-bcepilepsysociety：抗驚厥療法-公元前癲癇協(xié)會(已修改)
2025-01-24 06:44 本頁面
【正文】 Anticonvulsant Therapy Dr. Sia Michoulas Pediatric Epilepsy Fellow BC Children’s Hospital Outline ? Introduction ? Why do we treat seizures ? How do we select anticonvulsant medications ? Adverse Effects ? Drug Interactions ? Anticonvulsants and Pregnancy Epidemiology of Epilepsy ? 1 2 % of Canadians ?40, 000 people in BC ? Cerebral Palsy – 20% ? Autism – 2030% ? Developmental Delay 20% ? 3rd most mon neurologic disorder ?After Stroke and Alzheimer’s Seizure Manifestations Seizure Occurrence ? Up to 10% of the population will experience a single seizure during their lifetime ? majority due to an acute reversible cause: fever, metabolic changes, drug intoxication/withdrawal. ? Since seizures don’t recur in these patients after the provoking factor has been corrected, they don’t have a diagnosis of epilepsy. ? A diagnosis of epilepsy is made after a patient has had 2 or more unprovoked seizures What was the cause of the seizure? ? Epileptic seizures are symptoms due to a variety of causes ? Determining the underlying cause has implications for both treatment and prognosis Causes epileptic seizures Idiopathic (Geic) 50% of cases ? Childhood and Juvenile absence epilepsy ? Benign rolandic epilepsy of childhood ? Juvenile myoclonic epilepsy (JME) Symptomatic 50% of cases ? Malformations of brain developmental ? Tuberous Sclerosis ? Brain Infection ? Stroke ? Traumatic brain injury ? Tumor Clinical Factors Associated With Geic Versus Symptomatic Epilepsy Idiop a t hic E pileps y S ympt oma t i c E pilep sy 1. Nor mal d evelopmen t 2. Nor mal neur olo g ic al ex amin at ion 3. F amily histor y of ep ilep sy 4. No h ist or y of b r ai n i nj ur y (e. g . head traum a, meni ngiti s) ? C har act eristi c E E G ab n or maliti es ? Dev elop ment al Delay ? H ist or y of b r ai n i nj ur y ? A b nor mal Neur olo g ic al E xam ? Oth er cong en it al malfo r mati on s Why Do We
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