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tpharyngeal abscess Tuberculosis of Spine Clinical Manifestation ? Thoracic: – Back pain – Gibbous deformity ? Lumbar: – Special Standing stance ?Pickup test (+) ?Gravitation abscess ? Osseous destroy and decrease in one or more disc spaces ? Cold Abscess: – Cervical: ? Lumbar ? Thoracic Tuberculosis of Spine Roentgenographic Findings Principle of Treatment ? Cast fixation ? Surgical treatment – Evacuation or excision of soft tissue abscesses (切開排膿) – Clearance of focal lesion (病灶清除術(shù)) – Osteotomy, Arthrodesis and arthroplasty. (矯形手術(shù)) Hip Tuberculosis ? Clinical Manifestation – Hip pain – Limp – Abscess of groin – PE: ? Figure 4 test ? Hip hyperextension test ? Thomas test Hip Tuberculosis ? Roentgenographic Findings – Xray – CT – MRI Hip Tuberculosis ? Principle of Treatment – Chemotherapy – Skin traction to prevention forming contracture hip (bending deformity) then fix with hip spica for 3 months. – Simple synovial TB: ? Intraarticular injection with antitubercle medicine ? Synovectomy or curettage for the cases with intraarticular dropsy to reserve femoral head. (arthroscopy/ local lesion, open/extensive lesion) – Tuberculous panarthritis : ( antitb drug 1yr. ESR, CRP Normal.) ? Osteotomy, Arthrodesis and arthroplasty Case report ? 74 yrs, female, ? low back pain, radiate to the rt. leg, 6 months with hip pain ? limited in bed 2 months ? progressive weight loss, anorexia, no fever, ? Tenderness at the rt. groin of the hip ? Limited rang of motion of rt. hip, Thomas sign () ? Lab test : Wbc normal, CRP , ESR Oct. 26, 2022 Feb. 23, 2022 March 2, 2022 March 2, 2022 Hip joint aspiration ? Puslike liquid 5ml ? Culture () Q amp。 A ? Diagnosis ? ? Treatment? TB Controversy amp。 tendency ? Pathogenesis – immunologic research need to be go farther – farther study in gene level : ( HLA allele , ethnic differance。 IL6, IL8, IL10, TNFa) TB Controversy amp。 tendency ? Early diagnosis: the molecular biology technic is still a developmental tendency of study. – Gene probe technic(基因探針技術(shù)) , – Polymerase chain reaction(多聚酶鏈反應(yīng))– PCR – Nucleic acid amplification(核酸擴(kuò)增) in vitro… TB Controversy amp。 tendency ? Searching more ideal drug for TB with less side effect Thanks