08hostdefenseagainstinfect宿主防御-資料下載頁(yè)
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【導(dǎo)讀】AnatomicFactors. MechanicalFactors. BiochemicalFactors. Alveoli. Mucoussecretions. Stomach. SmallIntestine. Colon. Male. pHofurine. UrinarysIgA. Female(Vagina). Endocyticreceptors. IntegrinCD11b:CD18. Secretedproteins. C-reactiveprotein(CRP). Signalingreceptors. Tollreceptorfamily. Interleukin-1(IL-1). IL-6. Type1interferon(INF-I). Chemokines. T-c
【正文】 ion ? Opsonization/enhancement of phagocytosis ? Sensitization for killing by NK cells ? Sensitization of mast cells ? Activation of plement system Toxin Neutralization Diseases caused by bacterial toxins Preventing Bacterial Adherence Virusblocking Antibodies Activation of the Complement Cascade ? Cell Activation (anaphylatoxins) ? Activate inflammatory cells ? Induce smooth muscle contraction and blood vessel permeability ? Cytolysis (membrane attack plexes“) ? Loss of cell membrane integrity ? Opsonization ? Complement receptors on phagocytic cells ? Renders cells vulnerable to phagocytosis Fc Receptors Opsonization and Immune Adherence ? C3B (C4B) ? Facilitates adherence of bacteria, viruses and neutrophils to monocytes and macrophages ? Facilitates ingestion of certain bacteria by neutrophils and monocytes ? Facilitates ingestion by activated macrophages ? Augments mediated phagocytosis and IgGmediated cell cytotoxicity (ADCC) ? Antibody ? antibody may opsonize by itself, or bridge phagocyte and target cell, enhancing plement immune adherence Chemotaxis capillary blood vessel phagocyte endothelium basement membrane PAVEMENTING DIAPEDESIS CHEMOTAXIS C5a Site of inflammation, tissue damage and immune reactions Phagocytosis Bactericidal Agents in Phagocytic Cells Natural Killer Cells and AntibodyDependent CellMediated Cytotoxicity (ADCC) Inflammation ? Increased blood supply to the infected area ? Increased capillary permeability ? Migration of leukocytes into tissues (Chemotaxis) The four cardinal signs of inflammation (Cornelius Celsus, 30 BC to AD 38): rubor et tumor cum calore et dolore redness and swelling with heat and pain
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