動脈粥樣斑塊破裂進展(炎癥、信號轉(zhuǎn)導(dǎo)與他汀)-資料下載頁
2025-08-13 18:30本頁面
【導(dǎo)讀】21世紀-血管時代-心血管病根源。動脈粥樣硬化-最常見血管性疾病。冠心病-危害最大的血管性疾病。慢性病變-冠狀動脈狹窄。急性病變-斑塊破裂與血栓形成。內(nèi)皮功能紊亂學(xué)說。感染/炎癥成因?qū)W說。人為干預(yù)可使其消退。鈣質(zhì)被動沉積或退行性病變？，未明顯改善狹窄程度。緩解缺血與相應(yīng)癥狀。冠心病防治走向那里？不能改變斑塊的生。穩(wěn)定性斑塊：纖維帽所占比例>70%，斑塊的肩部，以巨噬細胞為主。冠脈內(nèi)張力變化?可使纖維帽的僵硬度和脆性增加，
【正文】 20mg 40mg 20mg 40mgMedian CRP Mean CRPDay 0Day 14Li JJ, et al. Clin Cardiol 2020。26:506511. 短期強化降脂臨床研究 Changes in mean lipid levels after simvastatin therapy over time ______________________________________________________________________ TC HDLC LDLC TG 20mg 40mg 20mg 40mg 20mg 40mg 20mg 40mg ______________________________________________________________________ Day 0 260? 264? 41 ? 42 ? 165? 163? 142? 147? Day 7 247? 232? 42 ? 40 ? 142? 138? 135? 136? Day 14 208? 192? 41 ? 44 ? 126? 112? 122? 118? Changes (%) Day 7 5% 14% +3% 5% 16% 18% 5% 8% Day 14 25% 38% 0% +5% 31% 34% 16% 25% _____________________________________________________________________ Li JJ, et al. Clin Cardiol 2020。26:506511. 短期強化降脂臨床研究 05010015020025030035020mg 40mg 20mg 40mg 20mg 40mg 20mg 40mgTC HDLC LDLC TGDay 0Day 7Day 14Li JJ, et al. Clin Cardiol 2020。26:506511. 單次大劑量他汀對 UA患者 48小時血CRP水平的影響 _____________________________________ Median CRP (mg/dl) Mean CRP(mg/ml) Time Sim 80mg/d placebo Sim 80mg/d placebo Day 0 ? ?.39 48 h late * ? * ? Change (%) () +() () +(10) ____________________________________________________ *p pared with day 0 Li JJ, et al. HeartDrug 2020。in press. 單次大劑量他汀對 UA患者 48小時血CRP水平的影響 0246810121416Sim 80mg/d placebo Sim 80mg/d placeboMedian CRP Mean CRPDay 048 hLi JJ, et al. HeartDrug 2020。in press. 他汀與急性冠狀動脈綜合征 Statins, like aspirin, should be given as early as possible in patients with acute coronary syndrome Li JJ. Medical Hypotheses, In press. 敬請批評指正！
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