信號分子與信號轉導signalingtransdu(編輯修改稿)
2025-05-23 13:51 本頁面
【文章內容簡介】 its localization to membrane, enzyme activity increase ? PH is a basic structure of protprot, protlipid interaction Ⅲ . adaptor proteins and scaffolding proteins ? adaptor protein a kind of mediator protein, Link one, upstream prot., to another, downstream ? role： recruit and anize the plex ? Most adaptor proteins contain two domains, no other special domain 1. adaptor protein Adaptor protein Nck SH2 C N SH3 SH3 SH3 HGFR, VEGFR, BCRAbl PDGFR, EphB1 SLP76, HPK1, p130cas IRS1,p62doc CKIg2,WASP,IRS1, DOCK180, NIK IRS1,DOCK180, Sos, NIK,Pak1,Pak3,NAP4,WIP,dynamin, synaptojanin、 Abl,cCbl Abl,cCbl,NAP1,Sam68 Sumaary of Section 4 1. Signaling plex exists at membrane and cytoskeleton structure. Within plex the special domain in a protein is a base of interacting with others. 1. Adaptor proteins and scaffolding proteins are the linker molecules in signaling and work. Section 5 General Signal Pathways Mediated by Membrane Receptors 膜受體介導的基本信號轉導通路 ? 3 types of membrane bound receptor： ?Ion channel receptor (ICR) ?Gprotein coupling receptor (GPCR) ?Single transmembrane receptor (STMR) ICR GPCR STMR 內源性配體 神經遞質 神經遞質、激素、趨化因子、外源刺激（味，光） 生長因子 細胞因子 結構 寡聚體形成的孔道 單體 具有或不具有催化活性的單體 跨膜區(qū)段數目 4個 7個 1個 功能 離子通道 激活 G蛋白 激活蛋白酪氨酸激酶 細胞 應答 去極化與超極化 去極化與超極化調節(jié)蛋白質功能和表達水平 調節(jié)蛋白質的功能和表達水平，調節(jié)細胞分化和增殖 Characters of 3 types receptors Ⅰ . Ion Channel Receptor ? structurally a channel, open or close pass through ion, ligandgated receptor channel ? Ligand: neurotransmitter mainly Acetyl choline receptor Acetylcholine Binding Site Ion channel overlook side look The role of Acetylcholin ? Ion channel memb. electric potential change chemical signal formation cell function ? Ion channel Cation channel: Acetyl Choline, Glutamic acid, 5Hydroxytrypotamine Ani
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