【文章內(nèi)容簡(jiǎn)介】
Antimetabolites ? 6Mercaptopurine (6MP) Site of action: inhibition of purine synthesis Application: Acute lymphoblastic leukemia (ALL) Adverse effects: bone marrow depression Antimetabolites ? 5Fluorouracil (5FU) Application: colorectal cancer Site of action: inhibition of thymidylate synthase (TS) and incorporation of its metabolites into RNA and DNA. Antibiotics ? Dactinomycin ? Doxorubicin and Daunorubicin ? Bleomycin ? Plicamycin disruption of DNA function Antibiotics ? Doxorubicin Site of action: a. Intercalation in the DNA b. Binding to cell membranes c. Generation of oxygen radicals through lipid peroxidation Adverse effects: Cardiotoxicity Doxorubicin O2 Reduced metabolite Superoxide ion Hydrogen peroxide Cytochrome P450 reductase St