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cause filariasis Four important filarial worms parasitic in humans are: Wuchereria bancrofti 班氏吳策線蟲 Onchocerca volvulus 旋盤尾絲蟲 Brugia malayi 馬來布魯線蟲 Loa loa 羅阿羅阿線蟲 W. bancrofti is strictly a human pathogen and is distributed in tropical areas worldwide More than 80 million were affected Orient, South Pacific, and Southern Asia to India – overlaps with Wuchereria bancrofti but does not occur in Africa or South America B. malayi infects a number of wild and domestic animals MorphologyAdults of Wuchereria bancrofti Adults occur in the lymphatic vessels ( Adult B. malayi are only half the size of W. bancrofti ) filariform larva 絲狀蚴 Microfilariae of Wuchereria bancrofti Microfilariae are seen in blood smears and are DIAGNOSTIC worms are 230320 181。m long Morphological differences of microfilariae of Wuchereria bancrofti and Brugia malayi Wuchereria bancrofti Brugia malayi Length 244296 177230 5 6 (181。m) Appearance graceful sweeping Irregular kinky 體態(tài) curves curves Cephalic space length equals width length twice width 頭隙 Body nuclei well defined, discrete, blurred, intermingled 體核 round, uniform sized nuclei crowded together Tail no terminal nuclei two terminal nuclei 尾核 Filariform larveinfective stage Microfilariae of Wuchereria bancrofti Nocturnal periodicity of microfilariae 夜現(xiàn)周期性 Pathology of Wuchereria bancrofti Incubation period no symptoms 3 clinical phases: 1. microfilaremia no symptoms or mild symptoms 微絲蚴血癥 Acute allergic inflammatory phase a. lymphadenitis, lymphangitis 淋巴結(jié)炎 淋巴管炎 Acute allergic inflammatory phase b. filarial fever 絲蟲熱 c. funiculitis, orchitis, epididymitis 精索炎, 睪丸炎,附睪炎 3. chronic Obstructive phase a. Elephantiasis 象皮腫 The disfigured legs of lymphatic filariasis patients waiting for medical attention b. chyluria 乳糜尿 c. hydrocele testis 鞘膜積液 Brugia malayi