【正文】 u ( I )T B T A( 1 m o l % )t B u O H / H2O = 1 / 1 ( V o l )r o o m t e m p e r a t u r eR1R2T B T A =NNNNNNNNNNB nB nB n1,2,3三唑雜環(huán)化合物 近年來 ， 還發(fā)現(xiàn)： 在 Cu(I)催化下 ， 疊氮化物 炔類的反應(yīng)速率可增加 大約 106 倍 ， 幾乎定量的選擇性地生成 1,4取代的 1,2,3三唑 ， 反應(yīng)能在各種溶劑中進(jìn)行 ， 甚至在純水中反應(yīng)也能很好地進(jìn)行 。 能 形成 C－ 雜原子鍵的有機(jī)反應(yīng) 有許多常見的實例 ， 如： * 不飽和化合物的環(huán)加成化學(xué) ， 尤其是 1,3偶極環(huán)加成 、 Diels – Alder加成 * 親核取代化學(xué) ， 張力雜環(huán)親電試劑 （ 如環(huán)氧環(huán) 、 氮丙啶 、 氮丙啶季胺鹽 、 環(huán)硫環(huán) ） * 非醇醛型羰基化學(xué) ， 如形成尿素 、 硫脲 、 芳香雜環(huán) 、 肟醚 、 腙 、 酰胺等的反應(yīng) * C－ C多鍵上的加成化學(xué) ， 如氧化至環(huán)氧化合物 、 氫化 、 氮丙啶化 、 親核試劑 Nu－ H的 Michael加成 常用鏈接化學(xué)的反應(yīng)類型 ： 是單純的融合過程 ， 即反應(yīng)物組成等于生成物組成 。 一般來說 ， 生命科學(xué)和石油化學(xué)已揭示了具有不同功能 /性質(zhì)的物質(zhì)的相同的合成策略：在選擇性催化劑控制下 ， 合成單體的模塊化集成 。 由生命體產(chǎn)生的分子總是吸引和激勵著合成化學(xué)家 。Prof. K. B. Sharpless, Prof. M. G. Finn Department of Chemistry The Scripps Research Institute 10550 North Torrey Pines Road La Jolla, CA 92037 (USA) Fax: (+1) 8587847562 Email: Dr. H. C. Kolb Vice President of Chemistry Coelacanth Corporation East Windsor, NJ 08520 (USA) K. B. Sharpless M. G. Finn H. C. Kolb K. Barry Sharpless and his coworkers have discovered and developed many widely used catalytic oxidation processes, including the first general methods for stereoselective oxidationthe Sharpless reactions for asymmetric epoxidation, dihydroxylation, and aminohydroxylation of olefins. His mentors at Dartmouth College (BA in 1963), Stanford University (PhD in 1968 and postdoctoral research), and Harvard University (further postdoctoral research) were Prof. T. A. Spencer, Prof. E. E. van Tamelen, Prof. J. P. Collman, and Prof. K. Bloch, respectively. Before 1990, when he became W. M. Keck Professor of Chemistry at The Scripps Research Institute, Prof. Sharpless was a member of faculty at the Massachusetts Institute of Technology (197077, 198090) and Stanford University (197780). Prof. Sharplesss honors include the Chemical Sciences Award of the National Academy of Sciences (of which he is a member), the Roger Adams and Arthur C. Cope Awards from the American Chemical Society, the Tetrahedron Award, the King Faisal Prize, the Prelog Medal, the Wolf Prize, and honorary doctorates from five American and European universities. The Sharpless research group continues to search for new homogeneous oxidation catalysts and for transition metal catalyzed asymmetric processes. M. G. Finn received his PhD degree from the Massachusetts Institute of Technology, working with Prof. K. B. Sharpless. This was followed by an NIH postdoctoral fellowship with Prof. J. P. Collman at Stanford University. He joined the faculty of the University of Virginia in 1988, and moved to his present position on the faculty of the Department of Chemistry and The Skaggs Institute for Chemical Biology at The Scripps Research Institute in 1998. His group has studied the reactivity of Fischer carbene plexes, metalsubstituted phosphorus ylides, and a variety of transition metal catalyzed processes. His current interests include methods for binatorial catalyst discovery and the use of viruses as molecular building blocks. Hartmuth Kolb received his PhD in synthetic anic chemistry under the supervision of Prof. S. V. Ley at Imperial College in London. After two years of postdo