人體腸道微生態(tài)最新研究資料-免費閱讀
【正文】 Gordon,. Mechanisms underlying the resistance to dietinduced obesity in germfree . Natl Acad. , 2007, 104, 979984.[31] Turnbaugh,. et al. An obesityassociated gut microbiome with increased capacity for energy harvest. Nature, 2006, 444, 10271031.[32] Manichanh,C. et al. Reduced diversity of faecal microbiota in Crohn’s diease revealed by a metagenomic approach. Gut, 2006, 55, 205211.[33] Joossens, M. et al. Dysbiosis of the faecal microbiota in patients with Crohn’s disease and their unaffected relatives. Gut2011, 60, 631637. [34] Larsen, N. et al. Gut microbiota in human adults with type2 diabetes differs from nondiabetic adults. PLoS ONE 5, e9085(2010).[35] GORBACH S L. The in testinalm icroflora and its cobn cancer conneetion [J]. Infection, 1982, 10(6): 379384.[36] 沈敏婕，靖大道.腸道微生態(tài)系統(tǒng)[J]. 胃腸病學(xué). 2003(01):3537.[5] 周慶德，微生物學(xué)教程（第二版）.北京,高等教育出版社，1993，.[6] Fredrik Backhed,Ruth E Ley,Justin L Sonnenburg, et al. HostBacterial Mutualism in the Human , 2005, 307(5717): 19151921.[7] 李亞丹，任宏偉，吳彥彬，等.另一方面，微生態(tài)制劑的使用考慮個體的差異的使用安全性。根據(jù)魏曉等[53]提出，通過利用元基因組的研究，全面系統(tǒng)的了解生理、病理狀態(tài)下腸道菌群結(jié)構(gòu)功能變化與疾病之間的關(guān)系，建立相應(yīng)的數(shù)據(jù)庫，然后將個體的病源微生物與其對比。還有許多相關(guān)的臨床試驗探索益生菌的安全性。如何進(jìn)行微生態(tài)制劑的安全性評估至關(guān)重要。而微生態(tài)制劑主要是靠其中含有的益生菌和（或）其代謝產(chǎn)物發(fā)揮作用。炎癥性腸病患者的腸道菌群成分和分布發(fā)生改變，與健康對照著有很大區(qū)別，包括細(xì)菌數(shù)量增加，乳酸桿菌和雙歧桿菌比例減低 [36]。在一般情況下，人體腸道的微生物菌群總數(shù)和比例相對比較穩(wěn)定，保持在平衡狀態(tài)。第三，腸道微生物對刺激宿主腸道免疫系統(tǒng)的發(fā)育。斷奶后，以雙歧桿菌、類桿菌、芽孢桿菌和鏈球菌為主要腸道菌群進(jìn)駐人體。從菌種及分布方面，人體腸道棲息著的菌屬主要包括有雙歧桿菌屬，乳酸桿菌屬，類桿菌屬，真桿菌屬等，雖然整個腸腔內(nèi)都存在大量細(xì)菌，但分布、濃度不一。結(jié)合目前最新的研究，對腸道微生態(tài)的進(jìn)行分析及展望。人體腸道微生態(tài)最新研究摘要：人體腸道中含有種類繁多的微生物，這些微生物在人體腸道中共同構(gòu)成腸道微生態(tài)。關(guān)鍵詞：腸道微生態(tài)；微生態(tài)制劑；益生菌 The latest study of the human gut microecologicalAbstract: In the human intestine，there is a wide variety of microorganisms. These microbes form the intestinal microecology. Gut is the living environment of microbes , and microbes is so beneficial to human. The types and the proportion of intestinal flora will change when human’s age or eating habit was changed. Intestinal microecology has two states, one is microecological balance and the other is microecological disturbance. Microecological can be regulated from disturbance to balance by useing probiotic and ( or ) its metabolites. With the rapid development of microecologics, the security problems of using probiotic are of concern. The research of human gut microecological as well as the security problems and the using of microecologics were been discussed in the article. According to the latest research, analysis and prospect about gut microecologi
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