抗糖尿病藥物基礎(chǔ)與臨床精簡(jiǎn)-預(yù)覽頁(yè)
【正文】 ates genes involved in fatty acid uptake and oxidation, inflammation, and vascular function ? PPARγ regulates genes involved in fatty acid uptake and storage, inflammation, and glucose homeostasis. ? PPARδ regulates genes involved in fatty acid metabolism, inflammation, and macrophage lipid homeostasis 2022/6/23 51 Dual agonists ?Possibilities: plementary effects and structural homology in energy homeostasis ?Current development Ragaglitazar, MK0767 ?Necessity: side effects of each class of agonists PPAR α/ γdual agonists Tesaglitazar, muraglitazar √ 2022/6/23 52 六、中藥 ? 金芪降糖片 ? 桑枝顆粒劑 2022/6/23 53 金芪主要藥理作用 1. 改善糖代謝，降血糖 2. 改善脂質(zhì)代謝，降血脂 (甘油三酯 ) 3. 改善胰島素抵抗，增強(qiáng)機(jī)體對(duì)胰島素的敏感性 4. 增強(qiáng)免疫功能 2022/6/23 54 H ypo gly ce m ic e ffec ts of Jin qi in a nimal modelsMo dels H y po g ly cemic eff ectsNormo l mice ++Allox a n diabetic mice ++Allox a n diabetic r a ts ++Spo ntaneo us db/ db mice ++V s con t ro l , ++ P 0 .01四氧嘧啶 2022/6/23 55 G roup s Liver glyco gen(m g/g)C han ges(% )C ontr ol ? 100 .0Jinqi ? ** 169 .1Effect of Jinqi on liver glycogen in normal mice 2022/6/23 56 Hypoglycemic effect of Jinqi in spontaneous diabetic mice（ C57 BL/KsJ db/+） 01002003003 . 0 g / kg 1 . 5 g / kgBlood glucose(mg/dl) Before After****2022/6/23 57 *******K K + J QN o rm a l0204060801001200 30 60 90 120T i m e ( m i n )Changes of blood glucose(%)KKEffects of Jinqi on insulin tolerance in diabetic KK mice 2022/6/23 58 0510152025nor. KK KK+JinqiInsulin (?u/ml) Sensitive indices (x104) Effects of Jinqi on serum insulin and sensitive indices to insulin in diabetic KK mice 2022/6/23 59 Thanks
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