【新整理】利用生物標(biāo)志物患者急性心血管疾病-全文預(yù)覽
【正文】 J Am Coll Cardiol 36:1812, 2000,CP10086425,TACTICS (TIMI 18),CP10368529,Conservative Invasive No. treatment treatment Primary endpoint 0.1 ng/mL 734 4.3 6.6 0.1 0.4 181 16.5 4.4 0.4 1.5 213 17.6 5.4 ?1.5 693 15.6 8.8 Death or MI 0.1 ng/mL 734 1.9 3.0 0.1 0.4 181 12.1 4.4 0.4 1.5 213 11.8 2.7 ?1.5 693 10.0 5.9,Cardiac troponin I,JAMA 286:2405, 2001,Favors invasive treatment,Favors Conservative treatment,Odds ratio,Relation Between Creatinine Clearance, Troponin T, and Outcomes,CURE Rates and Relative Risks of First Primary Outcome,CP10196541,NEJM 345:494, 2001,CP11894524,4 peptides related with each other regarding biochemistry and physiological function Atrial natriuretic peptide (ANP) Brain (or B type) natriuretic peptide (BNP) Ctype natriuretic peptide (CNP) Urodilatin, a slightly extended form of ANP,Natriuretic Peptide Family,Common 17amino acid ring structure Ring structure highly conserved 11/17 amino acids are homologous Ring structure essential for physiological activity,CP11894525,Natriuretic Peptide Family Biochemistry,Cardiomyocyte,Blood,proBNP (108 aa) BNP32 (proBNP 77108),BNP32 Physiologically active form,NTproBNP 176,Secretion LV stretch Wall tension,PreproBNP (134 aa),Signal peptide (26 aa),proBNP,Serin protease (Corin?),Mair: Scand J Clin Lab Invest, 1999,CP118945210,CP118945220,97.5% percentile (pg/mL),30 3039 4049 5059 ?60,Age groups,AgeSpecific Reference Range for NTproBNP,AHJ 149(4), April 2005,pg/mL,NTproBNP,pg/mL,BNP,Weight categories (BMI),Weight categories (BMI),?25,2529.9,?30,?25,2529.9,?30,P0.001,P0.001,Values of BNP and NTproBNP by Weight,CP118945221,38 177。g/L) Myo (98/56 181。 1.121.93,3.42。 1.382.40,1.64。g/L,P0.001,0.1 181。g/L,FRISCII,Death and MI at 30 days (%),0.03 181。95:20532059,Antman, 1998 1.1 (0.43.5) Benamer, 1998 13.7 (3.948.3) Brisisc, 1998 8.0 (0.965.1) Cin, 1996 17.9 (5.261.2) Galvani, 1997 6.6 (1.332.3) Hamm, 1992 11.7 (3.242.6) Luscher, 1997 2.5 (1.34.8) Ohman, 1996 4.7 (1.712.7) Olatidoye, 1998 156.1 (17.41,402) Ottani, 1997 6.6 (2.022.1) Rebuzzi, 1998 25.3 (5.2123.2) Solymoss, 1997 2.4 (0.78.1) Stubbs, 1996 1.5 (0.54.2) Wu, 1995 31.5 (6.7
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