13partnertrialpresentationslides-wenkub
2023-03-17 02:11:21 本頁面
【正文】 ortional hazards regression (multivariable analysis with covariates pvalue ) ? Effect of procedural plications on 3yr mortality studied with timedependent covariate analysis Study Flow 3 Years Alive = 132 Dead = 96 LTFU = 3 Withdrawal = 3 Ongoing F/U = 10 3 Years Alive = 119 Dead = 101 LTFU = 3 Withdrawal = 17 Ongoing F/U = 8 AVR (248) Randomized = 699 patients TF = 492 (70%) TA = 207 (30%) Transfemoral n = 492 TAVR (244) 3 Years Alive = 45 Dead = 52 LTFU = 1 Withdrawal = 0 Ongoing F/U = 6 3 Years Alive = 47 Dead = 42 LTFU = 1 Withdrawal = 10 Ongoing F/U = 3 AVR (103) Transapical n = 207 TAVR (104) % followup at 3 years % followup at 3 years % followup at 3 years % followup at 3 years Baseline Patient Characteristics Demographics Characteristic TAVR (n=348) AVR (n=351) n n Age – years (Mean 177。 SD) 347 177。 SVD = Structural Valve Deterioration Echocardiographic Findings (AT) Aortic Valve Area TAVR AVR 012Baseline 30 Days 6 Months 1 Year 2 Years 3 YearsValve Area (cm2) TAVRAVRError bars at 1 standard deviation p = NS No. of Echos p = p = p = NS p = p = NS p = NS p = NS 304 271 223 211 150 88 294 226 163 154 121 70 Echocardiographic Findings (AT) Mean Peak Gradients TAVR AVR 01020304050607080Baseline 30 Days 6 Months 1 Year 2 Years 3 YearsGradient (mmHg) Peak Gradient AVRPeak Gradient TAVRMean Gradient AVRMean Gradient TAVRNo. of Echos 310 277 233 219 155 88 299 230 169 158 123 72 Paravalvular Aortic Regurgitation (AT) 279 228 230 173 217 158 156 122 88 72 0%20%40%60%80%100%TAVR AVR TAVR AVR TAVR AVR TAVR AVR TAVR AVR30 Days 6 Months 1 Year 2 Years 3 YearsPercent of evaluable echos None Trace Mild Moderate SevereNo. of Echos p p p p p Impact of Total AR on Mortality (AT) TAVR Patients 131 121 114 102 93 80 63 171 146 125 117 110 94 62 34 24 21 18 15 12 9 NoneTr Mild ModSev 0%10%20%30%40%50%60%70%0 6 12 18 24 30 36Mortality Months post Procedure None TraceMildModerate SevereNo. at Risk % % % % % % % % % Impact of Mild PVL on Mortality (AT) TAVR Patients 168 150 142 130 120 106 81 139 119 98 91 83 67 42 24 18 16 14 13 11 9 NoneTr Mild ModSev 0%10%20%30%40%50%60%70%0 6 12 18 24 30 36Mortality Months post Procedure None TraceMildModerate SevereNo. at Risk % % % % % % % % % Mortality in Patients with NoneTrace AR (AT) TAVR vs AVR TAVR 131 121 114 102 93 80 63 AVR 256 205 192 184 165 147 109 0%10%20%30%40%50%60%70%0 6 12 18 24 30 36Mortality Months post Procedure TAVR
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