【正文】 具有抗菌活性的螺環(huán)化合物的合成 The Synthesis of Antibacterial Spiropounds 目錄 摘要 ................................................................................................................................................. I Abstract .........................................................................................................................................II 符號說明 .................................................................................................................................... III 引言 ................................................................................................................................................ 1 第 1 章 概述 ............................................................................................................................... 2 羰基烯烴化 ........................................................................................................................ 3 羰基烯烴化的研究進展 ................................................................................................ 4 Michael加成 ................................................................................................................... 5 Michael加成的研究進展 ............................................................................................ 6 硝基的還原 ........................................................................................................................ 7 催化加氫法 .................................................................................................................... 7 金屬還原法 .................................................................................................................... 8 用含硫化物還原 ............................................................................................................. 9 合成設計 ........................................................................................................................... 9 第 2 章 乙基 2(1苯基哌啶 4亞基 )乙酸酯的合成 .................................................10 試劑與儀器 ......................................................................................................................10 實驗部分 ..........................................................................................................................10 合成方法一 ...................................................................................................................10 合成方法二 ...................................................................................................................10 合成方法三 ................................................................................................................... 11 實驗小結 ..........................................................................................................................12 第 3 章 乙基 2(1芐基 4(硝基 甲基 )哌啶基 )乙酸酯的合成 .................................13 試劑與儀器 .......................................................................................................................13 實驗部分 ..........................................................................................................................13 合成方法一 ...................................................................................................................13 合成方法二 ...................................................................................................................13 合成方法二 ...................................................................................................................14 實驗小結 ..........................................................................................................................14 第 4 章 8芐基 2,8二氮雜螺 []癸烷 3酮的合成 ..................................................15 試劑與儀器 ......................................................................................................................15 實驗部分 ..........................................................................................................................15 合成方法一 ...................................................................................................................15 合成方法二 ....................................................................................................................16 合成方法三 ....................................................................................................................17 實驗小結 ...........................................................................................................