【正文】
KKME專業(yè)醫(yī)學(xué)搜索引擎 血必凈注射液對(duì)急性有機(jī)磷中毒性心血管損傷的干預(yù)研究 作者:王穎 ,榮廷 ,鄒艷果 ,李錦繡 作者單位:山東大學(xué)第二醫(yī)院急診科, 濟(jì)南 250033 【摘要】 目的 觀察血必凈注射液對(duì)急性有機(jī)磷中毒性心血管損傷患者外周血中性粒細(xì)胞核轉(zhuǎn)錄因子 ?kappa B(NF?Κ B)的活化程度及損傷預(yù)后的影響。方法 將 70 例急性有機(jī)磷中毒合并心血管損傷患者隨機(jī)分為陽(yáng)性對(duì)照組 (35 例 )和實(shí)驗(yàn)組 (35 例 ),用免疫酶組織化學(xué)法檢測(cè)其外周血中性粒細(xì)胞 NF?Κ B 的活化程度,并觀察患者血清心肌酶活性值的變化。結(jié)果 ①實(shí)驗(yàn) 組死亡率低于對(duì)照組 (P)。②對(duì)照組 NF?Κ B 活化程度高于實(shí)驗(yàn)組 (P)。③血必凈注射液呈劑量依賴性地抑制中性粒細(xì)胞 NF?Κ B 的活性 (P)。④實(shí)驗(yàn)組血清心肌酶活性值恢復(fù)程度優(yōu)于對(duì)照組,且與血必凈注射液用量呈劑量依賴性(P)。結(jié)論 早期聯(lián)合應(yīng)用血必凈注射液和常規(guī)治療藥物,可改善急性有機(jī)磷中毒并發(fā)心血管損傷患者的預(yù)后,提高救治成功率。 【關(guān)鍵詞】 血必凈注射液 ,有機(jī)磷中毒 ,心血管系統(tǒng) ,損傷 ,免疫組織化學(xué) ,核轉(zhuǎn)錄因子 ?Κ B To observe the effects of Xuebijing injection on nuclear factor? kappa B activation of PMN and the prognosis of cardiovascular injury. Methods 70 cases of acute anophosphate poisoning plicated with cardiovascular injury were divided into the positive control group (35 KKME專業(yè)醫(yī)學(xué)搜索引擎 cases)and the test group(35 cases) at random. The enzyme labeled immunohistochemical method was used to determine the NF?Κ B activation degree. Changes of myocardial enzyme were also observed. Results ① Death rate of the test group was lower than that of the control group(P). ② The NF?Κ B activation degree of the control group was higher t