【正文】 擦擠壓等情況。因此，優(yōu)良的復合纖維膜 需要優(yōu)異的力學性能才能發(fā)揮其最大的功能。將無序化和 圖案化 GE/CS/HA/GO 四元復合纖維 進行拉伸強度測試，并與GE/CS/HA 三元復合纖維進行對比。結(jié)果表明： 四元復合纖維明顯高于三元復合纖維，這是由于在四元系統(tǒng)中加入 GO，改善了纖維界面的粘接質(zhì)量，從而提高了拉伸強度。而 圖案化 GE/CS/HA/GO 四元復合纖維拉升強度達到了 。由于微結(jié)構(gòu)復合纖維的各項異性，微結(jié)構(gòu)纖維膜的拉伸強度大于無序纖維的拉伸強度。因此，該復合纖維材料表現(xiàn)出 良好的機械強度。 以上研究結(jié)果表明，本論文成功制備出 GE/CS/HA/GO 四元復合纖維，并分析表征其 空間分布和排列方式，提升了復合纖維的機械強度和抗菌性。有望使骨 II 修復材料在臨床醫(yī)學領(lǐng)域發(fā)揮出重要作用。 關(guān)鍵字： 氧化石墨烯； 圖案化纖維 ； 復合材料 ；蛋白吸附； 力學性能 III The Electrospinning GE/CS/HA/GO Composite Membrane Preparation And Performance Study Abstract:In recent years, the rapid development of biological materials, especially in bone repair materials. Thanks to the bone repair material can directly or indirectly treat disease or auxiliary repair damaged bones, but also has excellent patibility and biodegradability of the anism, and excellent mechanical strength and antibacterial property. This scheme can optimize the treatment of bone disease, reduce the risk of treatment or operation, and after implantation with human metabolism and degradation, the operation time necessary to remove two. The bone repair material prepared by electrospinning has high specific surface area and porosity, which is very beneficial to human bone cell growth, adhesion, differentiation, promote bone repair. But there is a certain human bone structure, so the use of micro pattern template of electrospun fibers, the posite fiber has a certain structure, more conducive to play the function of . Therefore, the preparation of GE/CS/HA/GO four posite fiber scaffolds for bone repair materials by electrospinning technique and patterned templates. And to explore the four element posite fiber GE/CS/HA/GO electrospinning conditions and the best parameters. The characterization of its morphology and properties. The research content includes the following parts: (1) to explore the optimal concentration of GO, the preparation of four element posite fiber GE/CS/HA/GO under optimal conditions based on GE/CS/HA three system results show that: by light and electron microscopy were obtained when the GO concentration is % and the template for the 200 mesh, the surface of fiber arranged orderly, uniform thickness, no bead and drop. Better morphology. (2) when the materials implanted in the human body, in order to ensure the supply of nutrients required for cells to repair, bone defect, posite materials have a certain adsorption on protein. The adsorption amount of four element posite fiber will be prepared at the optimal conditions of the bovine serum albumin in human body fluid environment. The results show that: the saturated adsorption amount of four yuan of GE/CS/HA/GO posite fiber BSA in %. With the increase of BSA and the pH value of the solution, the adsorption order disordered fiber surface and microstructure of BSA fiber surface is similar, but the effective area of the protein adsorption is different, resulting in the maximum adsorption capacity of BSA on the surface of the material pH value is slightly different. The initial concentration of BSA, the initial adsorption amount of fiber is larger, but it is to achieve balance in 20 min. (3) posite fibrous scaffold after implantation in the human body, such as friction extrusion by the surrounding tissue, an. Therefore, the need to fine fibrous scaffolds with excellent mechanical properties and maximize its function. The four element posite fiber disordering and patterned GE/CS/HA/GO tensile strength test, and pared with the three element posite fiber GE/CS/HA. The results showed that: four yuan three yuan was significantly higher than that of posite fiber IV posite fiber, this is due to the addition of GO in the four element system, improve the quality of fiber bonding interface, which improves the tensile strength of. The four element posite fiber patterning of GE/CS/HA/GO tensile strength reached . Due to the anisotropic microstructure of posite fibers, the tensile strength of the tensile strength of the micro structure fiber membrane is greater than that of disordered fiber. Therefore, the posites exhibit good mechanical strength. The above research results indicate that, this paper successfully prepared GE/CS/HA/GO four element posite fiber, and to characterize the spatial distribution and arrangement, enhance the antibacterial properties and mechanical strength of the posite fiber. Is expected to make the bone repair materials play an important role in the field of clinical medicine. Keywords: graphene oxide。 patterned fiber。 posite materials。 protein adsorption。 mechanical properties