【正文】 p and the normal group: The brain areas of increased Reho were found in right superior fontal gyrus, right superior medial gyrus, right inferior fontal gyrus, right anterior cingulate, left precuneus, left posterior cingulate, left superior temporal gyrus and the brain areas of decreased Reho were found in right inferior temporal Gyrus。2) Group parison between the later group and the normal group: The brain areas of increased Reho were found in left SII, left superior temporal gyrus, left superior frontal gyrus, left paracentral lobule, left cuneus, left precuneus, right inferior frontal gyrus, left posterior cingulate。 and the brain areas of decreased Reho were none 。3) Group parison between the recovered group and the normal group: The brain areas of increased Reho were found in left precuneus, left fusiform gyrus, left uncus。 and the brain areas of decreased Reho were none.Conclusions:(1) In the early group of facial paralysis, the brain areas of increased Reho was distributedineachleafof two sides cerebrumhemisphere, then in the later group, the brain areas of increased Reho was mainly distributed in the left cerebrumhemisphere, in the recovered group,the abnormal brain areas of Reho decreased, while still in the leftcerebrumhemisphere. The dynamic process of change before and after acupuncture treatment, suggested thepensatoryof the left cerebrumhemisphere. (2) The ReHo of facial paralysis in the different pathological stages (the early group, the later group and the recovered group) increased significantly, and mainly located in PMA(superior frontal gyrus,middle frontal gyrus), SMA(paracentral lobule), DMN(precuneus,PCC), ACC, SII, cuneus, superior temporal gyrus, only in the early group, the ReHomap in the right inferior temporal gyrusdecreased, the significant differences in the group parison between the recovered group and the normal group significantly reduced, which was of great clinical significance。(3) The brain areas of the premotor cortex(PMA), supplementary motor area(SMA) is likely to be the key areaof pensatory andbrainfunctional reorganization inpatients with peripheral facial paralysis inthe resting state, andmaybe the important modulationand the keypensatory region in the acupuncture treatment.(4) There is abnormal default mode network（DMN）in the brain areas of peripheral facial paralysis patience, the changesinduced by acupuncture,may also be the intrinsic mechanism of the acupuncture treatment.(5) Treatment of peripheral facial paralysiswithacupuncturemay bepleted through the pensatory ofthe ipsilateral cerebral hemisphere,the activation of the premotor cortexandthe supplementary motor area, andotherregions of the brainneuronsto collaborativeintegration.Keyword peripheral facial paralysis。 fMRI。 ReHo。 acupuncture。 cerebrum英文縮略詞表（Abbreviation and acronyms）ACPCAnterior CommissurePosterior Commissure 前后聯(lián)合線AFNIAnalysis of Functional NeuroImages功能性神經(jīng)影像分析ALFFAmplitude of Low Frequency Fluctuation 低頻振幅BoldBlood Oxygen Level Dependent 血氧水平依賴coefcoefficiency 系數(shù)CPUCentral Processing Unit 中央處理器CTComputed Tomography 計算機斷層顯像2Dtwo dimension 二維3Dthree dimension 三維DTIDiffusion Tensor Imaging 彌散擴散成像DICOMDigital Imaging and Communications in Medicine醫(yī)學(xué)數(shù)字成像和通信DMNDefault Mode Network 默認模式網(wǎng)絡(luò)ep2dechoplanner two dimension 平面回波二維成像EPIEchoplanar Imaging 平面回波成像技術(shù)FAFlip Angle 翻轉(zhuǎn)角度fMRIfunctional Magnetic Resonance Imaging 功能性磁共振成像FOVField of View 觀察視野FWHMFull Width Half Maximum半高全寬HzHertz 赫茲ICAIndependent Component Analysis 獨立成分分析jpgJoint Picture Group 圖像壓縮格式mmmillimeter 毫米msmillisecond 毫秒MRIMagnetic Resonance Imaging磁共振成像PACSPicture Achiving and Communication System 圖像存檔與傳輸系統(tǒng)PCPersonal Computer 個人計算機ACCAnterior cingulate cortex 前扣帶回PCCPosterior cingulate cortex 后扣帶回PETPositron emission tomography 正電子發(fā)射體層成像PWIPerfusion Weighted Imaging 灌注加權(quán)成像CCCorrelation coefficientSPECTSinglePhoton Emission Computed Tomography單光子發(fā)射計算機斷層成像rCBFregional Cerebral Blood Flow 局部腦血流量ReHoRegional Homogeneity 局部一致性ROIRegion Of Interest 感興趣區(qū)SESpin echo 自旋回波SLslice 層厚SPMStatistical Parametric Mapping 統(tǒng)計參數(shù)圖TTesla 特斯拉（場強單位）TETime of Echo 回波時間TITime of Inversion 反轉(zhuǎn)時間TRTime of Repeat 重復(fù)時間Tratransverse 橫軸位TSEturbo spin echo 快速自旋回波TTTalairach coordinate 標準坐標系T1WIT1weighted Imaging T1加權(quán)圖像T2WIT2weighted Imaging T2加權(quán)圖像DDDuration Data 持續(xù)時間KCCKendall39。s Coefficient of Concordance 肯德爾和諧系數(shù)HBHouseBrackmann 面神經(jīng)功能評價HB分級系統(tǒng)VBMVoxelBased Morphometry基于體素形態(tài)學(xué)分析PMAPremotor Areas 運動前區(qū)SMASupplementary Motor Area運動輔助區(qū)前言周圍性面癱，是一種臨床常見的自限性疾病，可發(fā)生于任何年齡，多發(fā)生于一側(cè)，急性起病，其主要特征表現(xiàn)為面部表情肌群運動功能障礙，一側(cè)面部表情肌麻痹，出現(xiàn)口角歪斜，額紋消失，眼裂增寬，閉目不緊，鼻唇溝變淺，鼓腮露氣，漱口漏水，不能做皺眉，露齒，鼓頰和噘嘴等動作，給患者帶來生活和社交方面的障礙[1 , 2]，其預(yù)后取決于面神經(jīng)的病變程度及治療是否及時恰當(dāng)[3]，若治療不及時或方法不當(dāng)，可留下后遺癥，嚴重影響容貌，降低生活質(zhì)量。該病的發(fā)病機制尚不十分明確，所以沒有標準的治療方法。而傳統(tǒng)中醫(yī)針刺是常用且有效的理想治療方式，針刺治療周圍性面癱歷史悠久，早在《內(nèi)經(jīng)》屮就有記載，積累了大量的經(jīng)驗，臨床上這種治療方法安全簡單，針刺可從整體上對機體進行調(diào)節(jié)使之處于穩(wěn)定的狀態(tài)，其療效確切，治愈率高[4]，為廣大患者所接受。 盡管針刺治療面癱效果顯著，也有臨床研究報道所證實[5]，然而針刺治療周圍性面癱的中樞機制尚不明確，有待研究探索。由于基于解剖成像的常規(guī)影像學(xué)檢查，諸如CT及MRI檢查在周圍性面癱中沒有明顯的陽性表現(xiàn)，隨著影像技術(shù)的飛速發(fā)展，磁共振功能成像技術(shù)(functional magnetic resonance imaging, fMRI) 已成為針刺研究一種重要的技術(shù)手段，并在周圍性面癱針刺治療的研究中發(fā)揮了越來越重要的作用。神經(jīng)活動和高分辨率磁共振成像技術(shù)相結(jié)合，做到了無侵入、無創(chuàng)傷的從形態(tài)和功能上探索活體腦高級皮質(zhì)活動。它是基于在神經(jīng)元活動的過程中，腦耗氧量和腦血流量變化不一致，而使得局部磁場發(fā)生變化，從而間接反映神經(jīng)元的活動，它依賴于腦的血氧水平的改變，稱為血氧水平依賴的fMRI(Blood oxygen level dependent functional MRI, BoldfMRI) [6]。BoldfMRI安全方便，成本較低，時空分辨率高，已成為了研究多種神經(jīng)精神疾病的新方法。Bold fMRI的研究設(shè)計根據(jù)掃描時所處的狀態(tài)分為刺激或任務(wù)相關(guān)(taskrelated)和靜息狀態(tài)(restingstate)的fMRI成像。任務(wù)態(tài)fMRI常被用于周圍性面癱的針刺研究，它是以針刺作為刺激任務(wù)進行fMRI研究的[7]，對面癱病人進行穴位電針刺的腦fMRI研究，發(fā)現(xiàn)了電針刺激左側(cè)合谷穴和左側(cè)地倉穴引起了左側(cè)和右側(cè)多個腦區(qū)信號的變化；也有以面部的肌肉運動作為任務(wù)來觀察研究面癱治療過程中的腦功能區(qū)變化[8]；同時，不需要任務(wù)刺激的靜息態(tài)功能連接分析也被應(yīng)用于面癱的研究，用于分析腦功能重組在面癱病人康復(fù)中的作用[9]，Klingner等[10]通過治療前后的fMRI對比分析，顯示面癱病人的病程發(fā)展變化過程中或者治愈后，fMRI發(fā)生變化，說明皮層功能重組在面癱疾病發(fā)生、發(fā)展以及治愈過程中有重要作用。既往