【正文】 p and the normal group: The brain areas of increased Reho were found in right superior fontal gyrus, right superior medial gyrus, right inferior fontal gyrus, right anterior cingulate, left precuneus, left posterior cingulate, left superior temporal gyrus and the brain areas of decreased Reho were found in right inferior temporal Gyrus。2) Group parison between the later group and the normal group: The brain areas of increased Reho were found in left SII, left superior temporal gyrus, left superior frontal gyrus, left paracentral lobule, left cuneus, left precuneus, right inferior frontal gyrus, left posterior cingulate。 and the brain areas of decreased Reho were none 。3) Group parison between the recovered group and the normal group: The brain areas of increased Reho were found in left precuneus, left fusiform gyrus, left uncus。 and the brain areas of decreased Reho were none.Conclusions:(1) In the early group of facial paralysis, the brain areas of increased Reho was distributedineachleafof two sides cerebrumhemisphere, then in the later group, the brain areas of increased Reho was mainly distributed in the left cerebrumhemisphere, in the recovered group,the abnormal brain areas of Reho decreased, while still in the leftcerebrumhemisphere. The dynamic process of change before and after acupuncture treatment, suggested thepensatoryof the left cerebrumhemisphere. (2) The ReHo of facial paralysis in the different pathological stages (the early group, the later group and the recovered group) increased significantly, and mainly located in PMA(superior frontal gyrus,middle frontal gyrus), SMA(paracentral lobule), DMN(precuneus,PCC), ACC, SII, cuneus, superior temporal gyrus, only in the early group, the ReHomap in the right inferior temporal gyrusdecreased, the significant differences in the group parison between the recovered group and the normal group significantly reduced, which was of great clinical significance。(3) The brain areas of the premotor cortex(PMA), supplementary motor area(SMA) is likely to be the key areaof pensatory andbrainfunctional reorganization inpatients with peripheral facial paralysis inthe resting state, andmaybe the important modulationand the keypensatory region in the acupuncture treatment.(4) There is abnormal default mode network（DMN）in the brain areas of peripheral facial paralysis patience, the changesinduced by acupuncture,may also be the intrinsic mechanism of the acupuncture treatment.(5) Treatment of peripheral facial paralysiswithacupuncturemay bepleted through the pensatory ofthe ipsilateral cerebral hemisphere,the activation of the premotor cortexandthe supplementary motor area, andotherregions of the brainneuronsto collaborativeintegration.Keyword peripheral facial paralysis。 fMRI。 ReHo。 acupuncture。 cerebrum英文縮略詞表（Abbreviation and acronyms）ACPCAnterior CommissurePosterior Commissure 前后聯(lián)合線(xiàn)AFNIAnalysis of Functional NeuroImages功能性神經(jīng)影像分析ALFFAmplitude of Low Frequency Fluctuation 低頻振幅BoldBlood Oxygen Level Dependent 血氧水平依賴(lài)coefcoefficiency 系數(shù)CPUCentral Processing Unit 中央處理器CTComputed Tomography 計(jì)算機(jī)斷層顯像2Dtwo dimension 二維3Dthree dimension 三維DTIDiffusion Tensor Imaging 彌散擴(kuò)散成像DICOMDigital Imaging and Communications in Medicine醫(yī)學(xué)數(shù)字成像和通信DMNDefault Mode Network 默認(rèn)模式網(wǎng)絡(luò)ep2dechoplanner two dimension 平面回波二維成像EPIEchoplanar Imaging 平面回波成像技術(shù)FAFlip Angle 翻轉(zhuǎn)角度f(wàn)MRIfunctional Magnetic Resonance Imaging 功能性磁共振成像FOVField of View 觀察視野FWHMFull Width Half Maximum半高全寬HzHertz 赫茲ICAIndependent Component Analysis 獨(dú)立成分分析jpgJoint Picture Group 圖像壓縮格式mmmillimeter 毫米msmillisecond 毫秒MRIMagnetic Resonance Imaging磁共振成像PACSPicture Achiving and Communication System 圖像存檔與傳輸系統(tǒng)PCPersonal Computer 個(gè)人計(jì)算機(jī)ACCAnterior cingulate cortex 前扣帶回PCCPosterior cingulate cortex 后扣帶回PETPositron emission tomography 正電子發(fā)射體層成像PWIPerfusion Weighted Imaging 灌注加權(quán)成像CCCorrelation coefficientSPECTSinglePhoton Emission Computed Tomography單光子發(fā)射計(jì)算機(jī)斷層成像rCBFregional Cerebral Blood Flow 局部腦血流量ReHoRegional Homogeneity 局部一致性ROIRegion Of Interest 感興趣區(qū)SESpin echo 自旋回波SLslice 層厚SPMStatistical Parametric Mapping 統(tǒng)計(jì)參數(shù)圖TTesla 特斯拉（場(chǎng)強(qiáng)單位）TETime of Echo 回波時(shí)間TITime of Inversion 反轉(zhuǎn)時(shí)間TRTime of Repeat 重復(fù)時(shí)間Tratransverse 橫軸位TSEturbo spin echo 快速自旋回波TTTalairach coordinate 標(biāo)準(zhǔn)坐標(biāo)系T1WIT1weighted Imaging T1加權(quán)圖像T2WIT2weighted Imaging T2加權(quán)圖像DDDuration Data 持續(xù)時(shí)間KCCKendall39。s Coefficient of Concordance 肯德?tīng)柡椭C系數(shù)HBHouseBrackmann 面神經(jīng)功能評(píng)價(jià)HB分級(jí)系統(tǒng)VBMVoxelBased Morphometry基于體素形態(tài)學(xué)分析PMAPremotor Areas 運(yùn)動(dòng)前區(qū)SMASupplementary Motor Area運(yùn)動(dòng)輔助區(qū)前言周?chē)悦姘c，是一種臨床常見(jiàn)的自限性疾病，可發(fā)生于任何年齡，多發(fā)生于一側(cè)，急性起病，其主要特征表現(xiàn)為面部表情肌群運(yùn)動(dòng)功能障礙，一側(cè)面部表情肌麻痹，出現(xiàn)口角歪斜，額紋消失，眼裂增寬，閉目不緊，鼻唇溝變淺，鼓腮露氣，漱口漏水，不能做皺眉，露齒，鼓頰和噘嘴等動(dòng)作，給患者帶來(lái)生活和社交方面的障礙[1 , 2]，其預(yù)后取決于面神經(jīng)的病變程度及治療是否及時(shí)恰當(dāng)[3]，若治療不及時(shí)或方法不當(dāng)，可留下后遺癥，嚴(yán)重影響容貌，降低生活質(zhì)量。該病的發(fā)病機(jī)制尚不十分明確，所以沒(méi)有標(biāo)準(zhǔn)的治療方法。而傳統(tǒng)中醫(yī)針刺是常用且有效的理想治療方式，針刺治療周?chē)悦姘c歷史悠久，早在《內(nèi)經(jīng)》屮就有記載，積累了大量的經(jīng)驗(yàn)，臨床上這種治療方法安全簡(jiǎn)單，針刺可從整體上對(duì)機(jī)體進(jìn)行調(diào)節(jié)使之處于穩(wěn)定的狀態(tài)，其療效確切，治愈率高[4]，為廣大患者所接受。 盡管針刺治療面癱效果顯著，也有臨床研究報(bào)道所證實(shí)[5]，然而針刺治療周?chē)悦姘c的中樞機(jī)制尚不明確，有待研究探索。由于基于解剖成像的常規(guī)影像學(xué)檢查，諸如CT及MRI檢查在周?chē)悦姘c中沒(méi)有明顯的陽(yáng)性表現(xiàn)，隨著影像技術(shù)的飛速發(fā)展，磁共振功能成像技術(shù)(functional magnetic resonance imaging, fMRI) 已成為針刺研究一種重要的技術(shù)手段，并在周?chē)悦姘c針刺治療的研究中發(fā)揮了越來(lái)越重要的作用。神經(jīng)活動(dòng)和高分辨率磁共振成像技術(shù)相結(jié)合，做到了無(wú)侵入、無(wú)創(chuàng)傷的從形態(tài)和功能上探索活體腦高級(jí)皮質(zhì)活動(dòng)。它是基于在神經(jīng)元活動(dòng)的過(guò)程中，腦耗氧量和腦血流量變化不一致，而使得局部磁場(chǎng)發(fā)生變化，從而間接反映神經(jīng)元的活動(dòng)，它依賴(lài)于腦的血氧水平的改變，稱(chēng)為血氧水平依賴(lài)的fMRI(Blood oxygen level dependent functional MRI, BoldfMRI) [6]。BoldfMRI安全方便，成本較低，時(shí)空分辨率高，已成為了研究多種神經(jīng)精神疾病的新方法。Bold fMRI的研究設(shè)計(jì)根據(jù)掃描時(shí)所處的狀態(tài)分為刺激或任務(wù)相關(guān)(taskrelated)和靜息狀態(tài)(restingstate)的fMRI成像。任務(wù)態(tài)fMRI常被用于周?chē)悦姘c的針刺研究，它是以針刺作為刺激任務(wù)進(jìn)行fMRI研究的[7]，對(duì)面癱病人進(jìn)行穴位電針刺的腦fMRI研究，發(fā)現(xiàn)了電針刺激左側(cè)合谷穴和左側(cè)地倉(cāng)穴引起了左側(cè)和右側(cè)多個(gè)腦區(qū)信號(hào)的變化；也有以面部的肌肉運(yùn)動(dòng)作為任務(wù)來(lái)觀察研究面癱治療過(guò)程中的腦功能區(qū)變化[8]；同時(shí)，不需要任務(wù)刺激的靜息態(tài)功能連接分析也被應(yīng)用于面癱的研究，用于分析腦功能重組在面癱病人康復(fù)中的作用[9]，Klingner等[10]通過(guò)治療前后的fMRI對(duì)比分析，顯示面癱病人的病程發(fā)展變化過(guò)程中或者治愈后，fMRI發(fā)生變化，說(shuō)明皮層功能重組在面癱疾病發(fā)生、發(fā)展以及治愈過(guò)程中有重要作用。既往