【正文】
acid (HA) ? Acyclovir Methods Pluronic F127 and F68 mixing in water are stirred at 4℃ Add Hyaluronic acid to poloxamers at room temperature formulations Acronyms F68 (% w/w) F127 (% w/w) HA (% w/w) Pol1 10 15 Pol2 15 15 Pol1/H05 10 15 Pol1/H08 10 15 Pol1/H1 10 15 1 Pol1/H2 10 15 2 Pol1/H1 15 15 1 Experiments ? Rheological characterization ? Photon correlation spectroscopy ? Mucoadhesion analysis ? In vitro release study Results Rheological characterization1 Fig. 2. Elastic and viscous moduli as a function of temperature of Pol1,Pol1/H1 and Pol1/H2 at a frequency value of Hz. Results are the means of three measurements. SD was always lower than 10%. Error bars are omitted for clarity purpose. Fig. 3. Elastic and viscous moduli as a function of temperature of Pol2 and Pol2/H1 at a frequency value of Hz. Results are the means of three measurements. SD was always lower than 10%. Error bars are mitted for clarity purpose. 由彈性模數(shù) G ′及黏性模數(shù) G 〞 曲線的交叉點可得知此種配方的膠體溶液的成膠溫度,而由 Pol Pol1/H1 、 Pol1/H2 、 Pol2 、 Pol2/H1的成膠溫度分別為 3 3 3 327 ℃ 。 R