課程：功能性高分子授課老師：謝慶東學生：魏伯翰學號：-資料下載頁
2025-10-08 10:32本頁面
【導讀】而此研究則使用PluronicF127及F68混合玻尿酸，設計。Acyclovir在模擬淚液中進行物要釋放測試。Poly之間的交互作用。PEO在高、低溫皆為親水。性，而PPO在低溫為親水；但在高溫則變成疏水性。型核心是由疏水的PPO聚合而成，而包覆在表面則是親水的PEO鏈。成膠現(xiàn)象乃是因Micelles之間相互糾結纏繞所形成。由β-1-3鍵結所鏈結而成的直鏈高分子多醣。透明質酸平均分子量介於。玻尿酸的分子能攜帶500倍以上的水分，為膠原蛋白。保水值可達1000cc/g，是當今文獻中公認之最佳。玻尿酸填充於人體的細胞與膠原纖維的空間中，且覆蓋在。條件下，G〞＞G′，由此篇文章定義來說這是未成膠的狀態(tài)，過了37℃後會是成膠的狀態(tài)。
【正文】 ferences ? A. Hatefi, B. Amsden, Biodegradable injectable in situ forming drugdelivery systems, J. Control. Release 80 (2020) 9–28. ? . Desai, J. Blanchard, Evaluation of pluronic F127based sustainedrelease ocular delivery systems for pilocarpine using the albino rabbit eye model, J. Pharm. Sci. 10(1998) 1190–1195. ? K. Lindell, S. Engstrom, In vitro release of timolol maleate from an in situ gelling polymer system, Int. J. Pharm. 95 (1993) 219–228. ? R. Gurny, T. Boye, H. Ibrahim, Ocular therapy with nanoparticulate systems for controlled drug delivery, J. Control. Release 2 (1985) 353–361. ? B. Srividya, . Cardoza, . Amin, Sustained ophthalmic delivery of ofloxacin from a pH triggered in situ gelling system, J. Control. Release 2–3 (2020) 205–211. ? K. Mortensen, W. Brown, B. Norden, Inverse melting transition and evidence of threedimensional cubatic structure in a block–copolymer micellar system, Phys. Rev. Lett. 15 (1992) 2340–2343. ? D. Dodou, P. Breedveld, . Wieringa, Mucoadhesives in the gastrointestinal tract: revisiting the literature for novel applications, Eur. J. Pharm. Biopharm. 1 (2020) 1–16.
教學課件相關推薦
鄂ICP備17016276號-1