【正文】
Mg2+主要存在細胞內(nèi),細胞外為5%,血Mg2+ ↓, 神經(jīng)和肌肉興 奮性↑(抽搐)。 2. 靜注:抑制CNS和外周神經(jīng)系統(tǒng)( Mg2+競爭Ca2+ , 影響Ach釋放——骨骼肌松弛;拮抗Ca2+—— 抑制心臟、舒張血管——降壓) 用途:① 抗驚厥用于子癇、破傷風(fēng)驚厥 ② 用于高血壓危象。,Summary,1. Phenytoin is one of the most effective drugs against partial seizures and generalized tonicclonic seizures. 2. Phenobarbital is useful in the treatment of partial seizures and generalized tonicclonic seizures. 3. Carbamazepine was initially marketed for the treatment of trigeminal neuralgia but has proved useful for epilepsy as well. Carbamazepine is also useful in some patients with mania (bipolar disorder).,第十九頁,共二十一頁。,內(nèi)容(n232。ng)總結(jié),癲癇(epilepsy):一類慢性、反復(fù)性、突然發(fā)作性大腦機能失調(diào),其特征為腦神經(jīng)元突發(fā)性異常高頻率放電并向周圍擴散。不抑制病灶高頻放電,阻止放電向正常組織擴散, 對正常低頻放電無影響。1. 廣譜抗癲癇藥,各種類型癲癇有效。Summary,第二十一頁,共二十一頁