高血壓防治的最終目標(biāo)----最大限度減少心腦血管事件-閱讀頁(yè)
2024-08-20 14:36本頁(yè)面
【正文】 N 高膽固醇血癥 血漿 Hcy水平 第 1位 5:1 19% 3% 15?mol/L ** HOPE2和依葉注冊(cè)臨床試驗(yàn) Engl J Med 2022。289:23632369 4. 北京大學(xué)學(xué)報(bào) (醫(yī)學(xué)版 ) 2022。26:48–62 Metaanalysis:MTHFR C677T and Stroke Risk In Chinese Population: OR=。 151: 862–877 北京大學(xué)學(xué)報(bào)（醫(yī)學(xué)版） 2022； (39)614618 Population frequency of homozygosity for the C677Tallele of 5,10methyleetrahydrofolate reductase (MTHFR) by geographic area and ethnicity China 25%! MTHFR C677T多態(tài)性與高血壓共同加重腦卒中發(fā)生的危險(xiǎn) 13 . 36 . 414 . 38 . 211 . 12 . 85 . 30 . 90 . 80123456789正常BP/非TT正常BP/TT高BP/非TT高BP/TT正常BP/非TT正常BP/TT高BP/非TT高BP/TT正常BP/非TT正常BP/TT高BP/非TT高BP/TTOR心腦血管事件腦卒中 死亡P P P= data on file 7th International Homocysteine Conference, Prague, Czech L o g i s tic R egr es s i o n * * Hy p ert ens i o n* MT HF R 6 7 7 TT To ta l ( N ) C as e ( N ) Pe r cen t ( ％ ) OR 9 5 % C I P D eath f r o m S tr o k e No 5 5 1 4 2 5 . 5 1 . 0 Yes 73 4 4 60 .3 4 . 2 1 . 8 9 . 8 0 . 0 0 1 No n mu t at e d 1 15 5 0 43. 5 1 . 0 M u t at e d 1 3 8 6 1 . 5 2 . 6 0. 7 9 . 9 0. 1 No No n mu t at e d 4 9 1 2 2 4 . 5 1 . 0 No M u t at e d 6 2 3 3 . 3 2 . 0 0. 3 1 4 . 5 0. 5 Yes No n mu t at e d 66 38 5 7 . 6 4 . 1 1 . 7 9 . 9 0 . 0 0 2 Yes M u t at e d 7 6 8 5 . 7 2 4 . 7 2 . 3 2 6 2 . 9 0 . 0 0 8 Odds Ratios of Fetal Stroke by MTHFR TT Genotype and Hypertension among Subjects with Moderate Hcy Level (=20umol/L) Hypertension definition: SBP=140mmHg and/or DBP=90mmHg and/or taking antihypertensive medication。 ? 評(píng)價(jià)在真實(shí)醫(yī)療環(huán)境下治療 H型高血壓，預(yù)防心腦血管事件發(fā)生的
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