殼聚糖基分子印跡磁性微凝膠的制備及釋藥特性doc-閱讀頁
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【正文】 omacromolecules, 2005, 6: 12801288.[8] Ana R D, Teresa C, Ana A R, et al. Supercritical fluid polymerisation and impregnation of molecularly imprinted polymers for drug delivery [J]. Journal of Supercritical Fluids, 2006, 39: 102–106.[9] Norell M C, Andersson H. S, Nicholls I A. Theophylline molecularly imprinted polymer dissociation kinetics: a novel sustained release drug dosage mechanism [J]. Journal of Molecular Recognition, 1998, 11: 98102.Preparation and Drug Release Properties of Molecularly Imprinted Magnetic Microgels based on ChitosanTANG Chunyan, WANG Hongfei，ZHANG Lingming(School of Chemistry and Chemical Engineering，Sun Yatsen University, Guangzhou 510275, China)Abstract Molecularly imprinted hydrogels (MIHs) have attracted more and more attention because of their enormous potential applications in the area of biosensor, separation and catalysis during the past decade. Caffeine imprinted magnetic microgel (Fe3O4 SiO2MIH) and nonimprinted magnetic microgel (Fe3O4SiO2nonMIH) were prepared by water in oil reverse emulsion method, using carboxymethyl chitoan (CMCS) as the functional polymer，genipin as the crosslinker，and silicamodified Fe3O4 as the magnetic ponent. The structures of Fe3O4 SiO2MIH were characterized by IR and XRD analyses. Fluorescence spectra confirmed the presence of the recognition sites. The microgels were wellshaped beads with the diameter distribution from 2 to 8 μm and were superparamagnetic. By invitro release study, the release rate of caffeine from Fe3O4 SiO2MIH was much slower than that from Fe3O4 SiO2nonMIH, and the release rate was dependent on the amounts of the template, and loading amount. The release test of theophylline from the caffeine imprinted microgel exhibited an inherent selectivity to caffeine. 【Keywords】Molecularly imprinted microgels 。 Genip
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