止血障礙血栓形成ppt課件-閱讀頁(yè)
2025-01-20 12:19本頁(yè)面
【正文】 teinemia ? Increased levels are associated with increased risk of arterial and venous thrombosis. ? Multiple effects on endothelial cells decreased thrombomodulin, increased TF activity, inhibition of NO and TPA Hyperhomocysteinemia ? Primary mutation of MTHFR gene ? Acquired vitamin B12, B6 or folic acid deficiency, hypothyroidism, isoniazid, methotrexate, theophylline Hereditary Thrombophilia ? Consider if : – family history of thrombosis – history of recurrent thrombosis – thrombosis at a young age – no acquired predisposing factors for thrombosis Malignancy ? Risk for thrombosis is multifactorial. ? Predominantly venous thrombosis stasis, tumor invasion of vessels, chemotherapy effects superimposed on acquired or primary defects in hemostasis. ? Distinct procoagulant (cysteine protease) found in many patients which can activate FX directly. Antiphospholipid Antibody Syndrome ? Autoimmune disorder, either primary or secondary, associated with an increased risk for arterial and venous thrombosis. ? Antibody is to cardiolipin in APA (ELISA as
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