免疫球蛋白４-在線瀏覽
2024-11-05 17:10本頁(yè)面
【正文】 g with one kind of heavy and one kind of light chain ? Why an individual B cell makes only makes antibodies of one specificity ? Why there is allelic exclusion Origin of Antibody Diversity History ? Definition – Diversity (repitoire) is the total of all the Ab specificities that an anism is capable of expressing ? Theories – Germ line theory – Somatic mutation theory Origin of Antibody Diversity Current concepts ? Multiple V genes ? VJ and VDJ joining ? Junctional diversity ? N region insertions – Amino acid sequences not encoded in the germ line D region T G G C C C Pro Trp C C C C C C V gene T G G D region C C C C C C V gene T G G C G G C C C Pro Arg C C C C C C V gene T G G D region C G C C C C Pro Pro GTCAATG GTCAATG + Break DNA TdT adds nucleotides Ligate N region insertion Intron J D J J J D D D Generation of N region insertions Origin of Antibody Diversity Current
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