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【正文】 L V ? 2 J?2 J?3 J?5 C? E J?1 J?4 Kappa light chain genes。 Vn=1000, Dn=15 P L V1 P L Vn P L V2 D2 D3 D1 Dn C? C? C?3 C? C ?2 C ?1 C ?4 C?1 C?2 J2 J3 J5 J1 J4 E CH1 H CH2 CH3 CH4 Heavy Chain Gene Family Gene rearrangement and expression P L V1 P L Vn P L V2 D2 D3 D1 Dn C? C? J2 J3 J5 J1 J4 E DJ rearrangement P L Vn P L V1 P L V2 D2 D1 C? C? J5 J4 E DNA VDJ rearrangement D2 C? C? J5 J4 E P L V1 P L V2 DNA Transcription D2 C? C? J5 J4 E L V2 RNA Primary transcript Heavy Chain Gene Family Gene rearrangement and expression E Primary transcript E J4 D2 V2 C? C? J5 L C? C? J5 L D2 J4 V2 RNA Processing An mRNA for C? C? L D J V C? L D J V An mRNA for C? Translation C? heavy chain C? L D J V C? L D J V C? heavy chain Transport to ER C? heavy chain V C C? D J V C? D J V C? heavy chain V C Mechanism of DNA Rearrangements ? Rebination signal sequences (RSS)
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