sodiumionchannel：鈉離子通道-在線瀏覽
2025-03-01 08:36本頁面
【正文】 ? Overview – Multiple Sclerosis (MS) displays a remissionrelapse course. Some axons are able to maintain minimal conduction velocity, while others degenerate pletely. ? Definition: Experimental autoimmune encephalomytis (EAE) – animal model of MS MS can display remissionrelapsing course. This is believed to be the result of the expression of two distinct isoforms of voltagegated Na+ channels NaV long distances ( 10μm) Bamyloid are pepties associated with neurodegenerative diseases, and can accumulate in fibrillar aggregates What is Important About This Article ? Nav is colocalized with a Na/Ca exchanger ? Nav is NOT colocalized with Bamyloid proteins ? Nav help restore conduction in demyelinated axons ? Nav is seen in degenerating axons An increase in yields an Increase in Na/Ca exchangers, elevating intracellular Ca2+ to harmful levels Article 3 Na+ Channels and the Conduction System of the Heart ? Long QT syndrome – disease where the entire cycle of excitationcontraction coupling of the myocardium is prolonged ? Patient had GA substitution at codon 1763 of the Nav channel gene, which changed a valine (GTG) to a methionine (ATG) ? This mutation produced a persistently active and fast recovering Na+ channel ? Mutant was INSENSITIVE to lidocaine Article 3 ? Authors generated a similar mutant by sitedirected mutagenesis ? Examined the mutant in a heterologous expression system to obtain biophysical and other properties The Nav V1763M mutant is Sensitive to TTX, but resistant to lidocaine TTX eliminates lidocaineinsensitive current Why this is important: Other than traumatic cardiac arrest, arrhythmias degenerate into ventricular fibrillation or ventricular tachycardias. “circus movement” whereby tissue bees “hyperexcitable” Extension and Application of Na+ Channel Properties and Function Relating to Article 3 Advanced Cardiac Life Support (ACLS) Targets Na+ Channels E
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