20xx年醫(yī)學專題—糖皮質激素與高血糖-展示頁
2024-11-14 04:51本頁面
【正文】 and lymphocytes by redistribution from circulation to lymphoid tissue Increase in the number of RBC, platelets, neutrophils,Actions of Glucocorticoids,第四頁，共四十四頁。,History,1855 – Addison39。nɡ xu233。 x237。)科 山東省內分泌代謝病臨床醫(yī)學中心 山東省臨床醫(yī)學研究院內分泌代謝病研究所,第一頁，共四十四頁。類固醇性糖尿病 Steroid diabetes,管慶波 山東省立醫(yī)院內分泌代謝(d224。ixi232。,概述 流行病學(linɡ b236。) 機制 診斷 治療,第二頁，共四十四頁。s disease 1856 – Adrenal glands essential for life 1930 – Cortex medulla 1932 – Cushing’s syndrome 1949 – Hench et al (Steroids in rheumatoid arthritis) 1952 – Aldosterone,第三頁，共四十四頁。,Anti inflammatory action: (Complex mechanism) Suppression of immunity Indirect inhibition of phospholipase A2 Alter other endocrine systems: Decrease in ACTH and TSH Increase in GH Effects on other systems: Increased production of gastric acid, pepsin Effects on CNS Bone loss Myopathy,Actions…Cont.,第五頁，共四十四頁。,常用糖皮質激素劑量(j236。ng)換算、作用、半衰期及效能,————————————————————————————————————— 藥 物 等效劑量 糖皮質激素作用 抗炎效價 鈉潴留作用 生物學半衰 期（小時） ————————————————————————————————————— 低效 可的松 25mg 0.8 2 8～12 8～36 氫化可的松 20mg 1 1.0 2 8～12 中效 強的松 5mg 4 3.5 1 12～26 強的松龍 5mg 4 4.0 1 12～36 甲基強的松龍 4mg 5 5.0 0 12～36 去炎松 4mg 5 5.0 0 12～36 高效(ɡāo xi224。,Adverse effects,Psychiatric Sleep disturbance/activation Mood disturbance Psychosis Skin/soft tissue Cushingoid appearance Abdominal striae Acne Hirsutism Oedema Neurologic Neuropathy Pseudomotor cerebri Cardiovascular Hypertension,Occur with prolonged use of high doses Cushing’s disease,MSK Osteoporosis Asceptic necrosis of bone Myopathy Endocrin
規(guī)章制度相關推薦
鄂ICP備17016276號-1