【正文】 .............................................. 6 天然青霉素的生產(chǎn)方法 ................................................................................. 6 半合成青霉素的生產(chǎn)方法 ............................................................................. 7 常見發(fā)酵方式 ............................................................................................................ 7 分批發(fā)酵 ......................................................................................................... 8 連續(xù)發(fā)酵 ......................................................................................................... 8 補(bǔ)料分批發(fā)酵 ................................................................................................. 9 工藝特點(diǎn) .................................................................................................................. 10 工藝流程 ...................................................................................................................11 發(fā)酵過程優(yōu) 化控制 ..................................................................................................11 發(fā)酵過程中溫度的控制 ................................................................................11 四川理工學(xué)院畢業(yè)設(shè)計(jì) IV 發(fā)酵過程中 pH的控制 .................................................................................11 發(fā)酵過程中溶解氧的控制 ........................................................................... 12 發(fā)酵過程中菌絲濃度的控制 ....................................................................... 12 發(fā)酵液質(zhì)量控制 ........................................................................................... 13 第三章 工藝計(jì)算 ................................................................................................................... 14 主要基礎(chǔ)數(shù)據(jù) : ........................................................................................................ 14 發(fā)酵罐設(shè)計(jì)技術(shù)指標(biāo) ............................................................................................. 15 物料衡算 .................................................................................................................. 15 能耗計(jì)算 .................................................................................................................. 19 水 .................................................................................................................... 19 蒸汽 ............................................................................................................... 21 空氣 ............................................................................................................... 21 第四章 設(shè)備設(shè)計(jì)及選型 ....................................................................................................... 23 主要設(shè)備設(shè)計(jì)及選型 ............................................................................................. 23 發(fā)酵罐 ........................................................................................................... 23 二級(jí)種子罐 ................................................................................................... 30 一級(jí)種子罐 ................................................................................................... 36 附屬設(shè)備設(shè)計(jì)及選型 ............................................................................................. 41 貯罐 ............................................................................................................... 41 液體輸送設(shè)備選型 ....................................................................................... 44 空氣粗過濾器 ............................................................................................... 45 空氣壓縮機(jī)選型 ........................................................................................... 45 發(fā)酵罐物料管道選型 ................................................................................... 46 二級(jí)種子罐物料管道選型 ........................................................................... 48 一級(jí)種子罐物料管道選型 ........................................................................... 50 第五章 車間布置 ................................................................................................................... 53 生產(chǎn)車間布置說明 ................................................................................................. 53 設(shè)備安裝 .................................................................................................................. 54 第六章 環(huán)境保護(hù) ................................................................................................................... 55 生產(chǎn)過程中“三廢”排放情況 ............................................................................. 55 處 理方案 .................................................................................................................. 55 目錄 V 噪聲控制 .................................................................................................................. 55 參考文獻(xiàn) .................................................................................................................................. 56 致謝 .......................................................................................................................................... 57 第一章 緒論 1 第一章 緒論 青霉素的發(fā)現(xiàn) 青霉素是一種高效、低毒、臨床應(yīng)用廣泛的重要抗生素。 volume。 關(guān)鍵詞： 青霉素 ； 發(fā)酵 ； 分批 ；工藝 ； 生產(chǎn) 四川理工學(xué)院畢 業(yè)設(shè)計(jì) II Abstract The design penicillin G sodium as the background, conduct an annual output of 1,200 tons sodium penicillin fermentation plant preliminary design process, in order to achieve P. Chrysogenum strain amplifying cultured smooth transition, the design with the current mainstream of the three fermentation production of penicillin , strain through seed fermentation seed after expanding culture into the secondary fermentation and then into the fermentation. By craft demonstration, seed pots and secondary seed medium was added in one jar fermentation fedbatch fermentation in order to ensure the healthy growth of P. ch