【正文】 ............................11 發(fā)酵過(guò)程優(yōu) 化控制 ..................................................................................................11 發(fā)酵過(guò)程中溫度的控制 ................................................................................11 四川理工學(xué)院畢業(yè)設(shè)計(jì) IV 發(fā)酵過(guò)程中 pH的控制 .................................................................................11 發(fā)酵過(guò)程中溶解氧的控制 ........................................................................... 12 發(fā)酵過(guò)程中菌絲濃度的控制 ....................................................................... 12 發(fā)酵液質(zhì)量控制 ........................................................................................... 13 第三章 工藝計(jì)算 ................................................................................................................... 14 主要基礎(chǔ)數(shù)據(jù) : ........................................................................................................ 14 發(fā)酵罐設(shè)計(jì)技術(shù)指標(biāo) ............................................................................................. 15 物料衡算 .................................................................................................................. 15 能耗計(jì)算 .................................................................................................................. 19 水 .................................................................................................................... 19 蒸汽 ............................................................................................................... 21 空氣 ............................................................................................................... 21 第四章 設(shè)備設(shè)計(jì)及選型 ....................................................................................................... 23 主要設(shè)備設(shè)計(jì)及選型 ............................................................................................. 23 發(fā)酵罐 ........................................................................................................... 23 二級(jí)種子罐 ................................................................................................... 30 一級(jí)種子罐 ................................................................................................... 36 附屬設(shè)備設(shè)計(jì)及選型 ............................................................................................. 41 貯罐 ............................................................................................................... 41 液體輸送設(shè)備選型 ....................................................................................... 44 空氣粗過(guò)濾器 ............................................................................................... 45 空氣壓縮機(jī)選型 ........................................................................................... 45 發(fā)酵罐物料管道選型 ................................................................................... 46 二級(jí)種子罐物料管道選型 ........................................................................... 48 一級(jí)種子罐物料管道選型 ........................................................................... 50 第五章 車間布置 ................................................................................................................... 53 生產(chǎn)車間布置說(shuō)明 ................................................................................................. 53 設(shè)備安裝 .................................................................................................................. 54 第六章 環(huán)境保護(hù) ................................................................................................................... 55 生產(chǎn)過(guò)程中“三廢”排放情況 ............................................................................. 55 處 理方案 .................................................................................................................. 55 目錄 V 噪聲控制 .................................................................................................................. 55 參考文獻(xiàn) .................................................................................................................................. 56 致謝 .......................................................................................................................................... 57 第一章 緒論 1 第一章 緒論 青霉素的發(fā)現(xiàn) 青霉素是一種高效、低毒、臨床應(yīng)用廣泛的重要抗生素。 關(guān)鍵詞： 青霉素 ； 發(fā)酵 ； 分批 ；工藝 ； 生產(chǎn) 四川理工學(xué)院畢 業(yè)設(shè)計(jì) II Abstract The design penicillin G sodium as the background, conduct an annual output of 1,200 tons sodium penicillin fermentation plant preliminary design process, in order to achieve P. Chrysogenum strain amplifying cultured smooth transition, the design with the current mainstream of the three fermentation production of penicillin , strain through seed fermentation seed after expanding culture into the secondary fermentation and then into the fermentation. By craft demonstration, seed pots and secondary seed medium was added in one jar fermentation fedbatch fermentation in order to ensure the healthy growth of P. chrysogenum. By process calculation, design selection 2 seed pots, three two seed pots, six fermentation tanks. Plant uses three design, put different types of tanks in different layers, in order to meet production needs. In this design, the design fully consider the theoretical amount of rationality, but also take into account the actual production of the feasibility of materials, energy and fermentation control factors calculations carried out, to let the design is plete and accurate. Key words: Penicillin。經(jīng)工藝論證，種子罐和二級(jí)種子罐培養(yǎng)基一次性 加入， 發(fā)酵罐采用補(bǔ)料分批發(fā)酵以 保證 產(chǎn)黃青霉的健康生長(zhǎng)。 （ 5）撰寫設(shè)計(jì)說(shuō)明書一份； （ 6）產(chǎn)品規(guī)格： 青霉素鈉鹽 ； （ 7）生產(chǎn)安排：年生產(chǎn)天數(shù)為 280 天 ； （ 8）淡旺季生產(chǎn)任務(wù)比例： 無(wú)淡旺季 ； 2．指定查閱的主要參考文獻(xiàn)及說(shuō)明 （ 1）吳思方 .發(fā)酵工廠工藝設(shè)計(jì)概論 [M].北京： 中國(guó)輕工業(yè)出版社 .20xx； （ 2）梁世中 .生物工程設(shè)備 [M].北京： 中國(guó)輕工業(yè)出版社 .20xx； （ 3）姚玉英 .化工原理 (上、下 )[M].北京： 天津大學(xué)出版社 .1999； （ 4）陸敏 . 化學(xué)制藥工藝與反應(yīng)器 [M].北京： 化學(xué)工業(yè)出版社 .20xx； （ 5） 季陽(yáng)萍 .化工制圖 [M].北京： 化學(xué)工業(yè)出版社 .2