炎癥性腸病ppt課件-展示頁
2025-01-24 20:53本頁面
【正文】 ion in normal mucosa (right) Histology U M SM M SM F Ulcerative colitis ?Mucosal inflammation only (M) ?Ulcers (U) Crohn180。 Bonini Clin Exp Allergy 2022 “Dirty” lifestyle High allergy Low allergy Th1 Th2 Hay fever Asthma Atopic eczema Food allergy Low microbial exposure Weak immune stimulation Crohn’s disease Strong immune stimulation Weak regulatory work: low IL10 and TGFb High microbial exposure A. Levine, 2022 Acute inflammation (Host defense) Physiologic/”controlled” inflammation Return to tolerance Pathologic/uncontrolled inflammation (IBD) Loss of tolerance Patterns of intestinal immune responses Food Flora Enteric flora T cell activation Proliferation Apoptosis Defective apoptosis Crohn’s disease Proliferation Apoptosis T cell activation Increased apoptosis Controlled inflammation T cell activation Proliferation Apoptosis Normal apoptosis Physiological inflammation Pathogens Dietary antigens Crohn’s disease Only small bowel 25 – 30 % Only colon 20 – 25 % Anorectal disease (anal fistulae, ascesses) 30 – 40 % Small bowel and colon 40 – 55 % Esophagus Stomach Duodenum 3 – 5 % Involvement of rectum 11 – 26 % Distribution of inflammatory bowel diseases Proctosigmoiditis 30 – 50 % (Sub)total colitis15 – 20 % ?b
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