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gina pectoris : ACS ?unstable angina pectoris ?STelevated AMI ?non STelevated AMI ?cardiac sudden death key point: pathophysiology 48 Company Logo Definition ACS: acute coronary syndrome ?ACS include UAP,NSTEAMI,STEAMI,and sudden death. ?ACS has the same pathophysiology,that is caused by suddenly rupture or erosion of atherosclerosis plaque and leading to formation of thrombosis .The results are from plete or partial occlusion of coronary arteries. 49 Company Logo Plaque rupture and thrombosis 完全閉塞 纖溶并殘存血栓 疾病進展 富含脂質斑塊 斑塊破裂 AMI UAP NQMI 再閉塞 部分閉塞 穩(wěn)定心絞痛 Adapted from Fuster V. N Engl J Med. 1992。s 22 Company Logo Gender unmodifiable risks(3) ?Until middle age, it is much more likely to occur in men than in women. After age fifty, however, the difference between the sexes nearly diminished. 23 Company Logo Gender (2) ?men are more often affected than woman by an overall ration of 4:1 ?40y, the ration 8:1 ?70y, the ration 1:1 24 Company Logo Modifiable risks ?Lowdensity lipoprotein cholesterol (dyslipidemia) ?Cigarette smoking ?Hypertension ?Diabetes mellitus ?Estrogen deficiency ?Inactivity ?Obesity 25 Company Logo Cholesterol levels —— lipoprotein ?LDL: lowdensity lipoprotein ?HDL: highdensity lipoprotein ?CM: chylomicron ?VLDL: verylowdensity lipoprotein 26 Company Logo ?LDL: carry cholesterol to arteries ?HDL: carry cholesterol back to liver ?most dangerous: lipoprotein(a), samll and density LDL ?in CAD patients, alwalys high LDLc, low HDLc 27 Company Logo 各組兔主動脈動脈粥樣硬化病變情況: