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【正文】 Am Heart J 2022; 151: 1187- 93 Department of Neurology Fudan University Huashan Hospital ACTIVE研究的設(shè)計(jì)與流程 確診 AF + ?1風(fēng)險(xiǎn)因素: 年齡 ?75,高血壓,曾患卒中/TIALVEF45, PAD 年齡 55–74 + CAD或糖尿病 不適合 OAC 的 AF患者 6707 pts 7554 pts 9018 pts Am Heart J 2022; 151: 1187- 93 Department of Neurology Fudan University Huashan Hospital ACTIVE W 研究 ? 在 AF患者(如能夠或者愿意使用 OAC), OAC與氯吡咯雷加 ASA相比, OAC顯著降低血管事件優(yōu)于抗血小板聯(lián)合治療 ACTIVE W: a randomized controlled trial. Lancet 2022。 95%CI ) 1 – Combination of aspirin and clopidogrel is less effective than warfarin and has a similar bleeding rate2 Atrial fibrillation (AF) 1: Hart RG et al.: Ann Intern Med (2022) 146:857867 2: Connolly S et al.: Lancet (2022) 367:19031912 Primary Prevention ? Background – Anticoagulation with an INR below is not effective – Increased risk for bleeding plications with an INR – Patients 65 years of age with “l(fā)one AF” (without other risk factors) are at low risk, whereas patients older than 65 years are at a higher risk for embolic stroke – Anticoagulation can be safe and effective in older individuals1, 2 Atrial fibrillation (AF) 1: Rash A et al.: Age Ageing (2022) 36:151156 2: Mant J et al.: Lancet (2022) 370:493503 Department of Neurology Fudan University Huashan Hospital 維生素 K拮抗劑用于房顫 ? 與阿司匹林相比,減少卒中達(dá) 38% ? 推薦用于高危房顫患者 ? 在西方國(guó)家僅有 4050%的理想患者可以接受 VKA1 ? 出血風(fēng)險(xiǎn)增加 ? 作用開始 /停止慢,治療窗窄 ? 為了調(diào)整劑量而需要監(jiān)測(cè)及追蹤 ? 飲食限制 ? 藥物相互作用 Thromb Thrombolysis. Feb 2022/p52/table 1 Department of Neurology Fudan University Huashan Hospital 中國(guó) AF患者抗凝治療的現(xiàn)狀 胡大一等。22:118123. Odds ratio for bedridden state following stroke due to AF was ( 95% CI, 。30(4):175–233. 2. Gage BF, Waterman AD, Shannon W, et al. JAMA. 2022。257–354) Department of Neurology Fudan University Huashan Hospital 不同國(guó)家的房顫患病率 Singh BN. Eur Heart J. 2022。288:2441–2448 *ASA is remended for patients at low risk of stroke( ACC/AHA/ESC Guideli
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