醫(yī)學免疫學課件】移植免疫學-文庫吧資料
2025-01-10 04:10本頁面
【正文】 疫學信息網 169。2022 免疫學信息網 169。2022 免疫學信息網 移植排斥反應的免疫學機制 針對移植物的細胞免疫應答機制： Tc、 TD 針對移植物的體液免疫應答機制： Ig介導 NK細胞參與的排斥應答機制：人 NK細胞表達 KIR，正常情況下，當此類受體與自身細胞 MHCI類分子或自身抗原肽 自身 MHCI類分子復合物結合時，可產生負調節(jié)信號，從而抑制 NK細胞的殺傷活性。2022 免疫學信息網 第一節(jié) 同種器官移植排斥的機制 在進行同種移植后，由于供、受者之間的組織相容性抗原不同，故移植物可刺激受者的免疫系統(tǒng)產生免疫應答，導致排斥反應。 169。2022 免疫學信息網 移植：在醫(yī)學上應用自體或異體的正常細胞、組織或器官置換病變的或功能缺損的細胞、組織或器官，以維持和重建機體的生理功能，這種治療方法稱為移植。2022 免疫學信息網 Early 1950’s Cortisonelike medications were used to suppress the human body’s selfdefense system (immune system), resulting in some kidney transplant success. 169。2022 免疫學信息網 1909 The first kidney transplant experiments were performed in humans in France using animal kidneys. o A surgeon inserted slices of rabit kidney into a child suffering from kidney failure. Although “the immediate results were excellent” the child died about 2 weeks later. o While such transplants did sucessfully produce urine, they lasted only for about an hour before ceasing to function. o Scientists of the time believed kidney transplants were possible, but their success was limited by unknown “biochemical barriers,” which prevente
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