對(duì)乙酰氨基酚論文：三廠家對(duì)乙酰氨基酚口服制劑生物等效性與體內(nèi)外(參考版)
2025-04-10 03:25本頁(yè)面
【正文】 ) h and (177。h. The dissolution parameters of Acetaminophen Tablet A, B and R were as follows, , and , Td , and :1. Multiple factor analysis of variance showed that main pharmacokinetic parameters such as AUC and Cmax, of Acetaminophen Tablets A, B and R had no significant differences between preparations and periods, but there were significant differences between individuals. Further bioequivalence of ttest met the statistical requirements and plied with the bioequivalent hypothesis, and three acetaminophen A, B, R tablets were . The dissolution in vitro of acetaminophen A, B, R tablets and absorption in vivo were well correlated in Cmax, Tmax and T50, Td, which indicated that in a certain extent, dissolution speed in vitro could reflect the absorption rate and degree in Tablets B and R were dissoluted to 100% within 15 min, but Tablet A was dissoluted to only 40% in 30 min. here are differences, Tmax of tablet A in vivo was (177。h and (177。h, (177。 AUC0～∞(177。)μgmL1)μgmL1 AUC0～15 (177。) h and (177。) h, Tmax (177。) h,(177。 To evaluate the inherent quality of acetaminophen tablets, to provide guideline for its r
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