味精安全問題ppt課件(參考版)
2025-01-21 08:00本頁面
【正文】 。 Simon RA. Additiveinduced urticaria: Experience with monosodium glutamate (MSG). J Nutr 130: 1063S1066S, 2022. Bazzano G, D39。 single and doubleblind studies using g MSG challenges vs placebo (capsules). ? 蕁麻疹：使用 （膠囊）治療 65例特發(fā)性蕁麻疹，單盲和雙盲研究 ? “ ..MSG is a distinctly unmon cause or exacerbant of chronic urticaria, if it induces urticaria at all. We were certainly unable to demonstrate MSGinduced urticaria in any of our chronic urticaria patients, even those who believed MSG provoked their urticaria in the past.” ? 即使味精會引發(fā)蕁麻疹，那也很少會引起或加劇慢性蕁麻疹。 ? n=0/130 met FASEB criteria for MSG sensitivity ? n=0/130 時符合 FASEB的 MSG過敏性實(shí)驗(yàn)標(biāo)準(zhǔn) Geha RS et al., J Allergy Clin Immunol 106:97380, 2022 CONCLUSION: Using criteria established by the 1995 FASEB panel, none of the individuals who claimed a sensitivity to MSG actually showed this sensitivity when tested under blinded conditions. 結(jié)論：根據(jù) 1995年美國實(shí)驗(yàn)生物學(xué)聯(lián)合會（ FASEB）制定的標(biāo)準(zhǔn)，對那些聲稱味精過敏的個體進(jìn)行雙盲試驗(yàn)表明他們未表現(xiàn)出敏感性。 none with placebo。 no symptoms with placebo. n=12 agreed to be studied. ? N=19時，實(shí)驗(yàn) A和 B的味精組都有超過 2種癥狀出現(xiàn)，安慰劑組沒有癥狀出現(xiàn)， n=12時，實(shí)驗(yàn)一致。 ? n=19 had ≥2 symptoms in A amp。 0/1 with MSG. ? 安慰劑組超過 2種癥狀出現(xiàn) +MSG組 1個 ? n=44: 0 or 1 symptoms with MSG amp。 0/1 with placebo. ? MSG組超過 2種癥狀出現(xiàn) +安慰劑組 1個 ? n=19: ≥2 symptoms with MSG amp。 placebo (sucrose) or MSG (5 g), in capsules (blind). Do three times. ? 實(shí)驗(yàn) D: 對 C中 MSG治療出現(xiàn)陽性反應(yīng)的實(shí)驗(yàn)對象，禁食，早餐加膠囊性安慰劑（蔗糖）或 MSG(5克 )，進(jìn)行盲試。重復(fù)實(shí)驗(yàn)。禁食，以 0， ， 5克MSG(液體 )進(jìn)行盲試。 Physiology, Filer LJ et al., ed. New York, Raven Press, 1979 , pp. 111123. 影響人體母乳二氨基酸濃度的因素 谷氨酸：生物化學(xué)和生理學(xué)進(jìn)展 Brain Issues 大腦問題 ? Relevance to human MSG ingestion: ? 有關(guān)人體攝入味精 ? The placenta blocks GLU transfer from maternal into fetal blood: FETAL brain is safe. ? 胎盤會阻止谷氨酸從母體傳遞給胎兒：胎兒大腦不會受到影響 ? Breast milk (GLU) does not rise when mother ingests highdose MSG: NEWBORN/INFANT brain is safe. ? 當(dāng)母體攝入大劑量的味精母乳中的谷氨酸含量不會上升：新生兒的腦發(fā)育是安全的 ? Infant metabolizes GLU at same rate as adult (Stegink et al., Pediatric Res 20: 5358, 1986). ? 嬰幼兒具有和成年人同樣的谷氨酸代謝的能力 Brain Issues大腦問題 ? The human brain is unaffected by the very high plasma (GLU) following high dose MSG intake ? 攝入大量的味精導(dǎo)致的血漿中高谷氨酸含量不會對人體大腦產(chǎn)生影響 ? No dose of MSG has yet been given to humans high enough to induce CNS effects. ? 至今亦未發(fā)現(xiàn)食用味精會影響人體中樞神經(jīng)系統(tǒng) CRS/Allergy (MSG Symptom Complex) 中國餐館綜合癥 /過敏癥 味精綜合癥 Studying MSG Symptom Complex 味
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