生化專題生物的調(diào)控(參考版)
2025-01-19 10:35本頁面
【正文】 ? Epigeic differences arise during the lifetime of monozygotic twins ?PNAS July 26, 2022 vol. 102 no. 30 060410609 ?We found that, although twins are epigeically indistinguishable during the early years of life, older monozygous twins exhibited remarkable differences in their overall content and genomic distribution of 5methylcytosine DNA and histone acetylation, affecting their geneexpression portrait. These findings indicate how an appreciation of epigeics is missing from our understanding of how different phenotypes can be originated from the same genotype. 表觀遺傳學(xué)和人類疾病 ?胃癌表觀遺傳學(xué)研究 ?免疫系統(tǒng)和表觀遺傳學(xué)調(diào)控：一個新的前沿領(lǐng)域 ?系統(tǒng)性紅斑狼瘡 (SLE)的表觀遺傳學(xué)發(fā)病機(jī)制研究進(jìn)展 植物的開花 FLOWERING LOCUS C (FLC) The Plant Journal Volume 44, Issue 3, Pages 420432， 2022 The downregulation of FLOWERING LOCUS C (FLC) expression in plants with low levels of DNA methylation and by vernalization occurs by distinct mechanisms Model for the Dual Control of Parental Genomic Imprinting by DNA Methylation in Plants The Plant Cell, Vol. 18, 1360–1372, June 2022 Small RNAs: How Seeds Remember To Obey Their Mother Maternal effects in maize Imprinting in Endosperm Development (A) Model for the Imprinting of FWA and FIS2. (B) Model for the Imprinting of MEA and PHE1. Cell 132, March 7, 2022 Establishment and maintenance of DNA methylation in Arabidopsis thaliana. NATURE GENETICS REVIEWS, VOLUME 6, MAY 2022: 351360 。 ? 一個重要的特征是，雙生子的差異性甲基化在啟動子的 CpG島上也有發(fā)生，表明可能會對基因的表達(dá)有影響。而且，表觀遺傳差別大小與雙生子間的分開時(shí)間長短及不同的醫(yī)療經(jīng)歷之間也有著聯(lián)系。其中有 65%的單卵雙生雙生子的表觀遺傳學(xué)特性基本保持一致，但仍然有著 35%的單卵雙生雙生子存在顯著的區(qū)別。但是，最近的一項(xiàng)研究卻是將單卵雙生他們內(nèi)在的差別作為引人入勝的考察對象：發(fā)現(xiàn)在單卵雙生中存在大量的表觀遺傳差異（ epigeic difference），表明了歲月和環(huán)境在不斷影響著人類健康的一個重要途徑。人類基因組序列草圖分析結(jié)果表明，人類基因組 CpG島約為 28890個，大部分染色體每 1 Mb就有 515個 CpG島，平均值為每 Mb含10． 5個 CpG島， CpG島的數(shù)目與基因密度有良好的對應(yīng)關(guān)系。 表觀遺傳學(xué)有如下三層含義： (1)可遺傳的，即這類改變通過有絲分裂或減數(shù)分裂，能在細(xì)胞或個體世代問遺傳； (2)是基因表達(dá)的改變； (3)沒有 DNA序列的變化或不能用序列變化來解釋。 表
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