臨床表現(xiàn)ppt課件(參考版)
2025-01-08 04:42本頁(yè)面
【正文】 postexposure Thanks ! 。Viral Hepatitis Dept. of Infectious Diseases SunYatsen University Introduction ? Viral hepatitis are a group of diseases, Caused by A、 B、 C、 D and E 5 hepatitis virus ? Hepatitis A and E Transmitted by fecaloral route, present acute and selflimited course ? Hepatitis B ,C and D Spread parenterally easily lead to chronic hepatitis ? Clinical characters including fatigue, intestinal symptoms tender and enlarged liver abnormal LFTs jaundice in some cases very variable in severity Significance Highly endemic Wide clinical spectrum High fatality rate in severe cases No specific pathogenic therapy available now Chronic hepatitis B and C very mon, some may develop to cirrhosis even HCC Successful vaccination for HBV and HAV EtiologyHAV Heparnavirus Appeared in bile and feces, spreaded via feces No chronic carrier status observed AntiHAV antibody to HAV AntiHAV IgM indicative of current or recent infection appeared very early, disappear in about 3months most useful for confirm the diagnosis Anti HAV IgG current or previous infection a protective antibody, conferring immunity persist for life long time EtiologyHBV ? Orthohepadnavirus, Dane particle ? 4 open reading frame: S,C,P,X ? 8 genotypes AH, B and C predominantly in China ? Strong ability against to environment ? 3 antigen and antibody system ? HBsAg found in serum and other body fluid not infectious itself suggesting current infection and infectivity AntiHBs a protective antibody to HBsAg an indicator of past infection and immunity to HBV reinfection suggesting noninfectious ? HBeAg suggesting HBV replication and high infectivity negative when preC mutation but with high level of replication useful for evaluation of antiHBV therapy AntiHBe
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