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s condition and needs, choose the most suitable mode of administration, to meet the needs of individual treatment [19]. References: [1] Shaikh IM, Jadhav KR, Ganga S, et approaches in insulin delivery [J].Curr Pharm Biotechnol, 2020,6 (5) :387395. [2]Chen Yan. Diabetes insulin Treatment of [M]. Beijing: Golden Shield Press ,2020:156159. [3] Zhong Yiping. insulin topical treatment of pressure ulcers [J]. Nurses Training Magazine, 2020,17 (1): 486. [4]Cefalu WT. Evolving strategies for insulin delivery and therapy [J]. Drugs, 2020,64 (11) :11491161. [5] Li Changchen Type 2 diabetes, evaluated the pros and cons of insulin therapy [J]. Practical Diabetology, 2020,10 (2): 10. [6]Brain the opportunity of tight glycaemic control inhaled insulin:Safety[J].Diabetes Obes Metab,2020,7(Suppl 1): 1418. [7]Gonzalez C,Kanevsky D,DeMarco R, routes forinsulin administration:Current state and perspectives[J].ExpertOpin Drug Deliv,2020,3(6):763770. [8]Cefalu strategies and feasibility of noninvasive insulin delivery[J].Diabetes Care,2020,27(1):239246. [9]Ramdas M,Dileep KJ, Anitha Y,et encapsulated bioadhesive chitosan microspheres for intestinal drug delivery[J].JBiomater Appl,1999,13(4):290296. [10] Wu Hung, Ping their best, Songbin Mei, et al. Chitosan and chitosan EDTA conjugates doublecoated oral insulin nanoliposomes [J]. Pharmaceutical University, 2020,39 (11): 933 938. [11] An Honglian, Xu Chunhua. insulin injections in different ways and nursing [J]. Practical Nursing, 2020,18 (9): 48. [12] to the Ding. diabetes, how to do 300 [M] . Beijing: Beijing Medical University and Peking Union Medical College Press, 1997:156. [13] Yungchi L, Pahala S, Samnel H, of brij78 on systemic delivery of insulin from an oculardevice [J]. J Pharm Sci, 1997, 86 (4): 430. [14] Owens DR, Zinman B, Bolli G. Alternative routes of insulin delivery [J]. Diabet Med, 2020,20 (11) :886898. [15] Cernea S, Raz I. Noninjectable methods of insulin administration [J]. Drugs Today (Barc), 2020,42 (6) :405424. [16] Wang Jing, Yin Shiyu, Gong Xiaoling. Noninsulin injection Research progress [J]. Nursing Research, 2020,21 (4B): 953. [17] Ryszka F, Calich B, Dolinska B, adminstration of progress [J]. Biol Chim Feim, 1993,132 (6): 197. [18] Barry BW. Novelmechanisms and devices to enable successful transdermal drug delivery [J]. Eur J Pharm Sci, 2020,1 (2): 101. [19] Zhao Jing, Jiang Liling. clinical nurse knowledge of master insulin Survey [J]. family nurse, 2020,4 (3B): 12. 。 deep muscle can gradually see the wound granulation, after 12 weeks of dressing, the wound healing scab. inhalation Relative to the absorption of peptide drugs, the lungs have more advantages, such as large alveolar surface area (50 m2 ~ 140 m2), very thin alveolar membrane, rich capillary work, and not the first highpermeability pass effect, narrow blood path, low activity, deep slow lung clearance rate, etc., these good physical environment for the absorption of peptide provided favorable conditions [4].In recent years, progressive pulmonary route of administration attention. INS inhalation require special technologies and facilities, mon technologies that are Techno sphere and AIR [5]. Most clinical trials show that in type 1 and type 2 diabetes patients, the inhaled and subcutaneous INS INS pared with the same safety and effectiveness,