【正文】 111(23):316784. 2. The Task Force Members, Dieter Horstkotte, Ferenc Follath, Erno Gutschik, et,al. Guidelines on Prevention, Diagnosis and Treatment of Infective Endocarditis— Executive Summary. Europe Heart Journal2020。⑥ 使用抗生素后培養(yǎng) ⑦ 霉菌性 IE ⑧ 立克次體、支原體等 19 抗微生物治療 TABLE 10. Overview of therpy for endocarditis caused by viridans group or streptococcus bovis Regimen Dosage and route Duration(per type of valve) Highly penicillinsensitive anisms Penicillin G 1218 million U/24 h either 4 weeks for native valve continuous or 46 doses 6 weeks for prosthetic OR Ceftriaxone sodium 2 g/24 h IV/IM in 1 dose 4 weeks for native valve 6 weeks for prosthetic OR Penicillin G plus Gentamicin Penicillin G 1218 million U/24 h either 2 weeks for native valve Continuous or 6 divided doses 6 weeks for prosthetic Gentamicin 3 mg/kg per 24h IV/IM in 1 dose 2 weeks for either 20 抗微生物治療 Regimen Dosage and route Duration(per type of valve) OR Ceftriaxone sodium plus gentamicin Ceftriaxone 2 g/24 h IV/IM in 1 dose 2 weeks for native valve 6 weeks for prosthetic Gentamicin 3 mg/kg per 24 h IV/IM in 1 dose 2 weeks for either OR Vanycin 30mg/kg per 24 h in 2 equal doses 4 weeks for native valve to maximum of 2 g/24 hrs 6 weeks for prosthetic Relatively penicillinresistant anisms (Penicillin or ceftriaxone) plus gentamicin Penicillin G 24million U/24 h either continuously 4 weeks for native valve Or 46 equally divided dose 6 weeks for prosthetic 21 抗微生物治療 Regimen Dosage and route Duration(per type of valve) OR Ceftriaxone 2 g/24 h IV/IM in 1 dose 4 weeks for native valve 6 weeks for prosthetic PLUS Gentamicin 3 mg/kg per 24 h IV/IM in 1 dose 2 weeks for native valve 6 weeks for prosthetic OR Vanycin 30 mg/kg per 24 h in 2 equal doses 4 weeks for native valve to maximum of 2 g/24 h 6 weeks for prosthetic 22 抗微生物治療 ? 營養(yǎng)變異性鏈球菌（ NVS）及青霉素高度耐藥者：萬古 6周 +慶大 6周 ? 肺炎鏈球菌：青霉素 4周或頭孢曲松 4周 ? 耐青霉素者：頭孢噻肟 4周或萬古 4周或頭孢曲松 +萬古 4周 23 腸球菌治療方案（一） ? Regimen Dosage and route Duration ? ? Susceptible to penicillin,gentamicin,and vanycin ? Ampicillin sodium 12g/24 h IV in 6 doses 4~6 weeks ? OR ? Penicillin G 1830million U/24h either continuously or 6 doses 4~6 weeks ? PLUS ? Gentamicin 3 mg/kg per 24h IV/IM in 3 equal doses 4~6 weeks ? OR ? Vanycin 30 mg/kg per 24h IV in 2 equally divided doses 6 weeks ? PLUS ? Gentamicin 3mg/kg per 24h IV/IM in 3 equal doses 6 weeks ? Susceptible to penicillin, streptomycin, vanycin, but resistant to gentamicin ? Amipicillin sodium 12 g/24h IV in 6 doses 4~6 weeks ? OR ? Penicillin G 1830 million U/24h either continuously or 6 doses 4~6 weeks ? PLUS ? Streptomycin sulfate 15mg/kg per 24