20xx年醫(yī)學(xué)專題—糖尿病與發(fā)炎指標(biāo)crp-資料下載頁
2024-11-14 01:45本頁面
【正文】 en With Type 2 Diabetes,Matthias B. et al. Diabetes Care 2004。27:16801687.,第二十二頁，共二十六頁。,The correlation matrix among changes of lipid profile and studied cardiovascular risk factors at the end of 12week fenofibrate treatment (n=39),第二十三頁，共二十六頁。,Changes of the Studied Risk Factors at the End of 12week Fenofibrate Treatment (n=39),第二十四頁，共二十六頁。,Binding and Internalization of Creactive Protein by Fcgamma Receptors on Human Aortic Endothelial Cells (HAEC) Mediates Biological Effects,Several reports showed that CRP binds to Fcgamma receptors on leukocytes. CRP (100 microg/mL) significantly upregulated surface expression of Fcgamma receptors, CD32, as well as CD64 on HAECs (P0.01). Preincubation with antiCD32 and CD64 antibodies significantly inhibited maximal binding of CRP to HAECs 64% and 30%, respectively, whereas antibodies to CD16 had no effect. Internalization of CRP, as determined by loss of surface expression, was 50%. Binding and internalization of biotinylated CRP was confirmed by confocal microscopy and CRP colocalized with CD32 and CD64. Most importantly, the increase in interleukin8, intercellular adhesion molecule 1, and vascular cell adhesion molecule1 and the decrease in eNOS and prostacyclin induced by CRP was abrogated with antibodies to CD32 and CD64. CONCLUSIONS: We demonstrate that CRP mediates its biological effects on HAECs via binding and internalization through Fcgamma receptors, CD32 and CD64.,Devaraj S, et al. Arterioscler Thromb Vasc Biol. 2005。 25:135963,第二十五頁，共二十六頁。,內(nèi)容(n232。ir243。ng)總結(jié),糖尿病與發(fā)炎指標(biāo)CRP。Obesity (BMI 30)。10 (suppl 1):S1S78.。C反應(yīng)蛋白(d224。nb225。i) (CRP)可加強(qiáng) TC/HDL比值預(yù)估首度心肌梗塞發(fā)生之風(fēng)險。*P0.001 vs pravastatin。HDL cholesterol (mmol/l)。LDL cholesterol (mmol/l)。25:135963,第二十六頁，共二十
合同協(xié)議相關(guān)推薦
鄂ICP備17016276號-1