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【正文】 efitinib 只對(duì)有特定 EGFR突變體的 NSCLC （ ~20%）有療效。這個(gè)發(fā)現(xiàn)為癌癥的個(gè)體化治療開創(chuàng)了先例。 AllelicPCR based diagnosis and sequencing 在這個(gè)發(fā)現(xiàn)中起了關(guān)鍵作用。 非小細(xì)胞肺癌 (NSCLC) 的治療 1) FDA approved in May 2023 for NSCLC, Gefitinib is currently marketed in over 64 countries. 2) In June 2023 the FDA withdrew approval for use in new patients due to lack of evidence that it extended life. Iressa/Gefitinib: Small Molecule ATP Competitor for EGFR Cheng et al, 2023, Modern Pathology, 25:347 EGFR Signaling Pathways (蛋白酪氨酸激 酶 受體 信號(hào)通道 ) Pao W et al。 Nature Cancer Review, 2023, 10:760 敏感性突 變 體 抗 藥 性突 變 體 敏感性突 變 體 : are activating mutations that make cancer cells are addictive to EGFR signaling and make the Gefitinib bind to ATP binding pocket of the mutant EGFR better 抗 藥 性突 變 體 : make Gefitinib unable to fit into ATP binding pocket Lynch TJ et al。 N Engl J Med 2023。 350:2129 蛋白酪氨酸激酶 抑制劑 Gefitinib 敏感和抗藥性的 EGFR點(diǎn)突變 Cheng et al, 2023, Modern Pathology, 25:347 蛋白酪氨酸激 酶 抑制劑 Gefitinib 敏感和抗藥性的 EGFR點(diǎn)突變 Pao W et al。 Nature Cancer Review, 2023, 10:760 有敏感性 EGFR點(diǎn)突 變 的病人群 EGFR Mutations and its Association to Responses to Gefitinib Therapy 無(wú) 篩選 病人群 Pao W et al。 Nature Cancer Review, 2023, 10:760 非小 細(xì) 胞肺癌 Gefitinib抗 藥 性的 多種途徑 Cheng et al, 2023, Modern Pathology, 25:347 The Discovery of EML4 and ALK Fusion in NSCLC ALK: Receptor Tyrosine Kinase Crizotinib: a small molecule specific inhibitor for ALK (PF) Whole genome wide sequencing and RNA seq Treating EML4ALK+ Advanced NSCLC with Crizotinib 1) 6個(gè)月療程 , 57% 的病人對(duì)治療有反應(yīng)。 2) 6個(gè)月 progressionfree survival 有 72%。 E. L. Kwak et al ., N. Engl. J. Med . 363, 1693–1703 (2023). Sci. Transl. Med. 2023, 4:120 AllelicPCR based diagnosis/sequencing 引起 Crizotinib抗 藥 性的 多種 ALK的點(diǎn)突 變 Sci. Trans. Med. 2023, 4:120 Imatinib Gefitinib Crizotinib ALK+肺癌 Crizotinib抗 藥 性的 多種途徑 ALK Amplification pEGFR Kit Amplication Cheng et al, 2023, Modern Pathology, 25:347 主要 驅(qū)動(dòng) （Driver） 突 變 基因在 非小 細(xì) 胞肺癌里出 現(xiàn) 的 頻 率 基因 檢測(cè) 技 術(shù) 謝謝觀看 /歡迎下載 BY FAITH I MEAN A VISION OF GOOD ONE CHERISHES AND THE ENTHUSIASM THAT PUSHES ONE TO SEEK ITS FULFILLMENT REGARDLESS OF OBSTACLES. BY FAITH I BY FAITH
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