細(xì)胞分化與基因表達(dá)調(diào)控-資料下載頁
2024-10-04 22:13本頁面
【正文】 es (1) Protooncogens: Gainoffunction mutations Ras oncogene: Retain bind GTP Bcl2 oncogene: Prevent apoptosis (2) Tumor suppressor genes: Lossoffunction mutations Rb gene: The first tumor suppressor gene in patient with retinoblastoma p53: Guardian of the genome Because the accumulation of gene mutation and Natural selection, so the patient is aged Chart of the major signaling pathways relevant to cancer in human cells, indicating the cellular locations of some of the proteins modified by mutation in cancers. Can we treat cancer? 1. Conventional approaches to bating cancer Surgery Chemotherapy/Radiation Can not rid of all cancer cells 2. Gene therapy Tumor cells lack functional tumorsuppressor genes p53bearing viruses Engineered adenovirus Immune response 3. Inhibiting the formation of blood vessels Angiogenesis: Cancer cells — growth factors — endothelial cells — form new vessels Dr. Folkman’s War: Angiogenesis and the struggle to defeat cancer Remember, you are only an expert from things done in the past. There are no experts from things that will happen in the future. Dr. Folkman
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