細(xì)胞凋亡與衰老-資料下載頁(yè)
2024-10-04 22:13本頁(yè)面
【正文】 activation of CAD, once activated, CAD translocates from the cytosol to the nucleus severing DNA into fragments. ?Enzymes involved in DNA repair. Which are inactivated by caspase cleavage. DNA repair is a homeostatic activity that is inappropriate in an apoptotic cell. Molecular pathways of apoptosis Two principle pathways Extrinsic pathway Intrinsic pathway (1) Extrinsic pathway: Fas Signaling Pathway Fas (also called Apo1 or CD95) is a member of the tumor necrosis factor receptor (TNFR) superfamily. Receptormediated pathway of apoptosis Bcl2 Family(cytoplasmic factors): Bad,Bid,and bax: promote apoptosis。 BclX, Bclw,and Bcl2: prevent apoptosis. Internal stimuli: DNA damage, high Ca2+ , Oxidative stress (2) Intrinsic pathway: Mitochondrial pathway The mitochondriamediated pathway of apoptosis Various types ofcellular stress Bcl2 family: Bad or Bax to bee inserted into OM of Mit Release of cytochrome c from IO space of Mit. Form a multisubunit plex。 and Caspase Cascade,… Activation of caspase2 is required for permeabilization of mitochondria, release of cytochrome c, and apoptosis Pathways to cell death in C. elegans and mammal
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