中藥有效成分及其類似物對乙酰膽堿酯酶的抑制作用研究doc-資料下載頁
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【正文】 ds.), Alzheimer39。s Disease:Therapeutic Strategies. Boston, Birkhauser, 1994:888 Canal N, Imbimbo B. Relationship between pharmacodynamic activity and cognitive effects of eptastigmine in patients with Alzheimer39。s disease. Eptastigmine Study Group. Clin. Pharmacol. Ther., 1996, 60:2182289 Mario B, Luigi F, Sperandina L, et al. New acetylcholinesterase inhibitors. Drugs Fut, 1997, 22:39741010 王立新， 韓廣軒，劉文庸等. 齊墩果酸的化學(xué)及藥理研究. 藥學(xué)實踐雜志， 2001, 19(2):10410611 AttaurRahman, Parveen S., Farooq A. et al. Acetylceolinesterase inhibiting triterpenoidal alokaoids from Buxus hyrcana. Heterocycles, 49, 481488Studies on Inhibition for ACh E by Active Compounds and Analogs in Chinese Traditional MedicineBao Yadan Ma Lin*(School of Chemistry and Chemical Engineering, Zhongshan University, Guangzhou 510275)Abstract Chinese Traditional Medicine is increasingly a focus of attention as a potential source of new drugs. In our research , some pounds (separated and synthesized) were used to examine their anticholinesterase activity . The presence of aromatic ring and conjugate structure was found to have good cholinesterase inhibitory activity when tested for the inhibition of electric eel acetylcholinesteras. Among them , pound 19c showed the most potent inhibitory activity (IC50=).Keywords acetylcholinesterase , inhibitor , IC50 , dynamics12 / 6
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