【正文】
19941999 St Bartolo Hospital,Vicenza,Italy 研究設(shè)計(jì)分組 Claudio Ronco,Rinaldo Bellomo et al,The lancet2022。356:2630 Group 1 Group 2 Group 3 Mean delivered ultrafiltration(L/24h) Mean effective blood flow (ml/min) 145 171 207 Mean duration of replacement(days) 11 13 12 Bleeding 5% 6% 4% Repeated filter clotting 3% 2% 2% Vascularaccess malfunction 10% 11% 12% Fluid balance errors 4% 6% 7% Effects of different doses in CVVH on outes of ARF .Ronco The Lancet. Vol 356. July 1, 2022 結(jié)果: 1組的中位生存率 19天,明顯短于 3組( G2 33天, P=。 G3 46天仍有 53%存活 ,P=), Effects of different doses in CVVH on outes of ARF .Ronco The Lancet. Vol 356. July 1, 2022 并發(fā)敗血癥者需要更高的劑量 無(wú)敗血癥 敗血癥 P值 第一組 55/126(44%) 5/20 (25%) 第二組 76/122(62%) 3/17(18%) 第三組 74/125(59%) 7/15(47%) Survival rates stratified by trial group and presence of sepsis IRRT vs CRRT: the difference The difference is not timing The important differences are ? dose ? fluid The most important clinical difference is DOSE ? timing is part of dosing ? timing as an independent variable? ARF 治療時(shí)推薦的劑量 What is mon practice in our hospital? CVVH 超濾率 3050 升 /天,在少尿或無(wú)尿后 1224小時(shí)之內(nèi)開(kāi)始; 如果 ARF 是敗血癥的一部分或治療無(wú)敗血癥的 SIRS,超濾量應(yīng)該達(dá)到 7080 L/天。 Eric ,van Bommel et al:AJKD 1997。30。s72s79 討論與結(jié)論 治療劑量是影響急性腎衰預(yù)后的重要因素。 對(duì)于 CVVH,治療劑量 =超濾量; 對(duì)于平均 70kg的急性腎衰病人,盡早開(kāi)始血液濾過(guò),置換液量至少 2L/小時(shí)。 技術(shù)并發(fā)癥低的原因與下面因素有關(guān): A:熟練的技術(shù)人員; B :仔細(xì)與精確的監(jiān)測(cè)治療過(guò)程。