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【正文】 ncode 20 aminoacids, “Start” and “Stop” SG’s first task: Sequence the domains (or families) From Science. 2022 Apr 18。300(5618):44552 SCOP statistics 生物大分子結(jié)構(gòu)與功能的關(guān)系： 功能 =運(yùn)動(dòng)著的結(jié)構(gòu) 生命是由蛋白復(fù)合物納米機(jī)器運(yùn)轉(zhuǎn)著 ?Some say: Function is structure! ?Others say: Structure is function!! ?I say: Functions are structures in motion!!! The ribosome translates the mRNA sequence into protein sequence Ramakrishnan (2022), Cell 108, 557572 The structure of the large and small ribosomal subunit Schematic surface representation with animation 23S RNA: orange 5S RNA: yellow proteins: blue Active site: green Ban, Nissen, Hansen, Moore amp。 Steitz (2022) Nissen, Hansen, Ban, Moore amp。 Steitz (2022) The Elongation Cycle studied by CryoEM 1 3 4 5 2 E P A R How do ~100 RNA helices in 6 RNA domains pack together and form a pact structure? The large ribosomal subunit contains a ~100 197。 long tunnel for product release the polypeptide exit tunnel. Nonstick surface “teflon” mixed surface of hydrophobic and polar patches 謝謝大家
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